Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography

Graves' ophthalmopathy (GO) involves autoimmune activation of fibroblasts, resulting in chronic inflammatory reaction. Somatostatin receptors are expressed in the cells associated with chronic inflammation. We hereby present patients with active GO, with delayed response to the standard treatme...

Descripción completa

Detalles Bibliográficos
Autores principales: Arora, Saurabh, Damle, Nishikant Avinash, Meel, Rachna, Lata, Kanak, Tandon, Nikhil, Sharma, Sanjay, Bal, Chandrasekhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Interesting Image
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771202/
https://www.ncbi.nlm.nih.gov/pubmed/31579195
http://dx.doi.org/10.4103/ijnm.IJNM_147_19
Descripción
Sumario:Graves' ophthalmopathy (GO) involves autoimmune activation of fibroblasts, resulting in chronic inflammatory reaction. Somatostatin receptors are expressed in the cells associated with chronic inflammation. We hereby present patients with active GO, with delayed response to the standard treatment regimen, in whom (68)Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) was planned to evaluate the orbital inflammation. (68)Ga-DOTANOC PET/CT shows no physiological orbital muscle uptake. It can provide information which may possibly of utility in response assessment and also screening patients who fail to respond to conventional treatment, for newer therapies such as long-acting somatostatin analogs.

Ejemplares similares