Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography

Graves' ophthalmopathy (GO) involves autoimmune activation of fibroblasts, resulting in chronic inflammatory reaction. Somatostatin receptors are expressed in the cells associated with chronic inflammation. We hereby present patients with active GO, with delayed response to the standard treatme...

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Autores principales: Arora, Saurabh, Damle, Nishikant Avinash, Meel, Rachna, Lata, Kanak, Tandon, Nikhil, Sharma, Sanjay, Bal, Chandrasekhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Interesting Image
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771202/
https://www.ncbi.nlm.nih.gov/pubmed/31579195
http://dx.doi.org/10.4103/ijnm.IJNM_147_19
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author Arora, Saurabh
Damle, Nishikant Avinash
Meel, Rachna
Lata, Kanak
Tandon, Nikhil
Sharma, Sanjay
Bal, Chandrasekhar
author_facet Arora, Saurabh
Damle, Nishikant Avinash
Meel, Rachna
Lata, Kanak
Tandon, Nikhil
Sharma, Sanjay
Bal, Chandrasekhar
author_sort Arora, Saurabh
collection PubMed
description Graves' ophthalmopathy (GO) involves autoimmune activation of fibroblasts, resulting in chronic inflammatory reaction. Somatostatin receptors are expressed in the cells associated with chronic inflammation. We hereby present patients with active GO, with delayed response to the standard treatment regimen, in whom (68)Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) was planned to evaluate the orbital inflammation. (68)Ga-DOTANOC PET/CT shows no physiological orbital muscle uptake. It can provide information which may possibly of utility in response assessment and also screening patients who fail to respond to conventional treatment, for newer therapies such as long-acting somatostatin analogs.
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spelling pubmed-67712022019-10-02 Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography Arora, Saurabh Damle, Nishikant Avinash Meel, Rachna Lata, Kanak Tandon, Nikhil Sharma, Sanjay Bal, Chandrasekhar Indian J Nucl Med Interesting Image Graves' ophthalmopathy (GO) involves autoimmune activation of fibroblasts, resulting in chronic inflammatory reaction. Somatostatin receptors are expressed in the cells associated with chronic inflammation. We hereby present patients with active GO, with delayed response to the standard treatment regimen, in whom (68)Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) was planned to evaluate the orbital inflammation. (68)Ga-DOTANOC PET/CT shows no physiological orbital muscle uptake. It can provide information which may possibly of utility in response assessment and also screening patients who fail to respond to conventional treatment, for newer therapies such as long-acting somatostatin analogs. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6771202/ /pubmed/31579195 http://dx.doi.org/10.4103/ijnm.IJNM_147_19 Text en Copyright: © 2019 Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Interesting Image
Arora, Saurabh
Damle, Nishikant Avinash
Meel, Rachna
Lata, Kanak
Tandon, Nikhil
Sharma, Sanjay
Bal, Chandrasekhar
Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography
title Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography
title_full Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography
title_fullStr Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography
title_full_unstemmed Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography
title_short Graves' Ophthalmopathy on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography
title_sort graves' ophthalmopathy on (68)ga-dotanoc positron emission tomography/computed tomography
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771202/
https://www.ncbi.nlm.nih.gov/pubmed/31579195
http://dx.doi.org/10.4103/ijnm.IJNM_147_19
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