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Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening

Rationale: The idiosyncratic drug-induced liver injury (iDILI) is a major cause of acute liver injury and a key challenge in late-stage drug development. Individual heterogeneity is considered to be an essential factor of iDILI. However, few in vitro model can predict heterogeneity in iDILI. We have...

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Detalles Bibliográficos
Autores principales:	Wang, Zhenyu, Li, Weijian, Jing, Hongshu, Ding, Ming, Fu, Gongbo, Yuan, Tianjie, Huang, Weijian, Dai, Mengjun, Tang, Dan, Zeng, Min, Chen, Yi, Zhang, Hongdan, Zhu, Xuejing, Peng, Yuan, Li, Qigen, Yu, Wei-Feng, Yan, He-Xin, Zhai, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771233/ https://www.ncbi.nlm.nih.gov/pubmed/31588244 http://dx.doi.org/10.7150/thno.34520

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