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Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases
CONTEXT: Preeclampsia is often asymptomatic, and hence, its detection depends on signs or investigations. The platelet (PLT) parameters, in cases of preeclampsia with normal PLT count, are seldom analyzed. Hence, this study was undertaken to study the PLT parameters in nonthrombocytopenic preeclamps...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771321/ https://www.ncbi.nlm.nih.gov/pubmed/31579247 http://dx.doi.org/10.4103/JLP.JLP_161_18 |
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author | Reddy, Shilpa Gopal Rajendra Prasad, Chinaiah Subramanyam Babu |
author_facet | Reddy, Shilpa Gopal Rajendra Prasad, Chinaiah Subramanyam Babu |
author_sort | Reddy, Shilpa Gopal |
collection | PubMed |
description | CONTEXT: Preeclampsia is often asymptomatic, and hence, its detection depends on signs or investigations. The platelet (PLT) parameters, in cases of preeclampsia with normal PLT count, are seldom analyzed. Hence, this study was undertaken to study the PLT parameters in nonthrombocytopenic preeclampsia cases. AIM: The aim was to evaluate the use of PLT indices as severity markers in nonthrombocytopenic preeclampsia cases. SUBJECTS AND METHODS: This prospective study was done on 120 cases of severe preeclampsia, 115 cases of preeclampsia without severe features, and 203 normal pregnant women admitted in the obstetrics wards during the study period of 1 year. The PLT indices obtained by analyzing anticoagulated blood were recorded. STATISTICAL ANALYSIS USED: Analysis of variance test was used to see the significance of association. Receiver operating characteristic (ROC) curve and binary regression analysis was used to estimate the cutoff value and examine the predictive value of the PLT parameters in the disease progression of preeclampsia. RESULTS: Even in the absence of thrombocytopenia, mean platelet volume (MPV) and PLT distribution width were significantly higher in severe preeclampsia group (P < 0.001) and were also positively correlating with mean arterial pressure (r = 0.38 and 0.20, respectively). ROC curve analysis showed that MPV had the highest area under the curve of 0.78 (95% confidence interval [0.719–0.842]). Cutoff value of >10.95 fl for MPV was found to have significant predictive value for disease progression in preeclampsia. CONCLUSIONS: Even in the absence of thrombocytopenia, PLT indices, especially MPV, have a good diagnostic significance in detecting severe preeclampsia. Further studies are required to evaluate their role as biomarkers in preeclampsia. |
format | Online Article Text |
id | pubmed-6771321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-67713212019-10-02 Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases Reddy, Shilpa Gopal Rajendra Prasad, Chinaiah Subramanyam Babu J Lab Physicians Original Article CONTEXT: Preeclampsia is often asymptomatic, and hence, its detection depends on signs or investigations. The platelet (PLT) parameters, in cases of preeclampsia with normal PLT count, are seldom analyzed. Hence, this study was undertaken to study the PLT parameters in nonthrombocytopenic preeclampsia cases. AIM: The aim was to evaluate the use of PLT indices as severity markers in nonthrombocytopenic preeclampsia cases. SUBJECTS AND METHODS: This prospective study was done on 120 cases of severe preeclampsia, 115 cases of preeclampsia without severe features, and 203 normal pregnant women admitted in the obstetrics wards during the study period of 1 year. The PLT indices obtained by analyzing anticoagulated blood were recorded. STATISTICAL ANALYSIS USED: Analysis of variance test was used to see the significance of association. Receiver operating characteristic (ROC) curve and binary regression analysis was used to estimate the cutoff value and examine the predictive value of the PLT parameters in the disease progression of preeclampsia. RESULTS: Even in the absence of thrombocytopenia, mean platelet volume (MPV) and PLT distribution width were significantly higher in severe preeclampsia group (P < 0.001) and were also positively correlating with mean arterial pressure (r = 0.38 and 0.20, respectively). ROC curve analysis showed that MPV had the highest area under the curve of 0.78 (95% confidence interval [0.719–0.842]). Cutoff value of >10.95 fl for MPV was found to have significant predictive value for disease progression in preeclampsia. CONCLUSIONS: Even in the absence of thrombocytopenia, PLT indices, especially MPV, have a good diagnostic significance in detecting severe preeclampsia. Further studies are required to evaluate their role as biomarkers in preeclampsia. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6771321/ /pubmed/31579247 http://dx.doi.org/10.4103/JLP.JLP_161_18 Text en Copyright: © 2019 Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Reddy, Shilpa Gopal Rajendra Prasad, Chinaiah Subramanyam Babu Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases |
title | Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases |
title_full | Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases |
title_fullStr | Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases |
title_full_unstemmed | Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases |
title_short | Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases |
title_sort | significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771321/ https://www.ncbi.nlm.nih.gov/pubmed/31579247 http://dx.doi.org/10.4103/JLP.JLP_161_18 |
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