Cargando…

Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles

BACKGROUND: Hydatidiform mole (HM) is characterized histologically by cystic swelling of the chorionic villi, accompanied by variable trophoblastic proliferation. The most important reason for the correct recognition of moles is that they are associated with an increased risk of persistent trophobla...

Descripción completa

Detalles Bibliográficos
Autores principales: Mondal, Santosh Kumar, Mandal, Saikat, Bhattacharya, Saptarshi, Panda, Utpal Kumar, Ray, Arpan, Ali, Sk. Moyaraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771328/
https://www.ncbi.nlm.nih.gov/pubmed/31579240
http://dx.doi.org/10.4103/JLP.JLP_130_19
_version_ 1783455669549006848
author Mondal, Santosh Kumar
Mandal, Saikat
Bhattacharya, Saptarshi
Panda, Utpal Kumar
Ray, Arpan
Ali, Sk. Moyaraf
author_facet Mondal, Santosh Kumar
Mandal, Saikat
Bhattacharya, Saptarshi
Panda, Utpal Kumar
Ray, Arpan
Ali, Sk. Moyaraf
author_sort Mondal, Santosh Kumar
collection PubMed
description BACKGROUND: Hydatidiform mole (HM) is characterized histologically by cystic swelling of the chorionic villi, accompanied by variable trophoblastic proliferation. The most important reason for the correct recognition of moles is that they are associated with an increased risk of persistent trophoblastic disease (invasive mole) or choriocarcinoma. AIMS AND OBJECTIVES: The aim of the study was to determine whether there is any role of p57 in differentiating partial and complete moles by immunohistochemical staining. MATERIALS AND METHODS: A prospective observational study was undertaken in which 40 cases of molar pregnancy included over a period of 2 years. Detailed clinical and family histories were obtained from each patient. Histopathological examination followed by immunohistochemical study with p57 done in each case. Ultrasonography findings and serial titers of serum beta-human chorionic gonadotropin were noted whenever necessary. RESULTS: Among the forty cases included, 25 (62%) had complete molar (CM) pregnancy, whereas the rest 15 (38%) had partial mole (PM). Both CM and PM were more pronounced in the age group of 20–25 years (44% and 60%, respectively), and among nulliparous women (68% and 70% respectively), 17 (42.5%) mothers had a prior history of abortion. In the histologically unequivocal cases of complete mole, 96% (24 of 25) did not express p57 and a single case was focal positive. In contrast, it was strongly and continuously expressed in both villous cytotrophoblast and stromal cells in all cases of PM (15 of 15). CONCLUSION: p57 immunomarker is very helpful to diagnose and differentiate complete and partial HM.
format Online
Article
Text
id pubmed-6771328
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-67713282019-10-02 Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles Mondal, Santosh Kumar Mandal, Saikat Bhattacharya, Saptarshi Panda, Utpal Kumar Ray, Arpan Ali, Sk. Moyaraf J Lab Physicians Original Article BACKGROUND: Hydatidiform mole (HM) is characterized histologically by cystic swelling of the chorionic villi, accompanied by variable trophoblastic proliferation. The most important reason for the correct recognition of moles is that they are associated with an increased risk of persistent trophoblastic disease (invasive mole) or choriocarcinoma. AIMS AND OBJECTIVES: The aim of the study was to determine whether there is any role of p57 in differentiating partial and complete moles by immunohistochemical staining. MATERIALS AND METHODS: A prospective observational study was undertaken in which 40 cases of molar pregnancy included over a period of 2 years. Detailed clinical and family histories were obtained from each patient. Histopathological examination followed by immunohistochemical study with p57 done in each case. Ultrasonography findings and serial titers of serum beta-human chorionic gonadotropin were noted whenever necessary. RESULTS: Among the forty cases included, 25 (62%) had complete molar (CM) pregnancy, whereas the rest 15 (38%) had partial mole (PM). Both CM and PM were more pronounced in the age group of 20–25 years (44% and 60%, respectively), and among nulliparous women (68% and 70% respectively), 17 (42.5%) mothers had a prior history of abortion. In the histologically unequivocal cases of complete mole, 96% (24 of 25) did not express p57 and a single case was focal positive. In contrast, it was strongly and continuously expressed in both villous cytotrophoblast and stromal cells in all cases of PM (15 of 15). CONCLUSION: p57 immunomarker is very helpful to diagnose and differentiate complete and partial HM. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6771328/ /pubmed/31579240 http://dx.doi.org/10.4103/JLP.JLP_130_19 Text en Copyright: © 2019 Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mondal, Santosh Kumar
Mandal, Saikat
Bhattacharya, Saptarshi
Panda, Utpal Kumar
Ray, Arpan
Ali, Sk. Moyaraf
Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles
title Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles
title_full Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles
title_fullStr Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles
title_full_unstemmed Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles
title_short Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles
title_sort expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771328/
https://www.ncbi.nlm.nih.gov/pubmed/31579240
http://dx.doi.org/10.4103/JLP.JLP_130_19
work_keys_str_mv AT mondalsantoshkumar expressionofp57immunomarkerintheclassificationanddifferentialdiagnosisofpartialandcompletehydatidiformmoles
AT mandalsaikat expressionofp57immunomarkerintheclassificationanddifferentialdiagnosisofpartialandcompletehydatidiformmoles
AT bhattacharyasaptarshi expressionofp57immunomarkerintheclassificationanddifferentialdiagnosisofpartialandcompletehydatidiformmoles
AT pandautpalkumar expressionofp57immunomarkerintheclassificationanddifferentialdiagnosisofpartialandcompletehydatidiformmoles
AT rayarpan expressionofp57immunomarkerintheclassificationanddifferentialdiagnosisofpartialandcompletehydatidiformmoles
AT aliskmoyaraf expressionofp57immunomarkerintheclassificationanddifferentialdiagnosisofpartialandcompletehydatidiformmoles