USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation

The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases. Cancer genomic analysis identified frequent amplification of USP21 (22%) in human pancreatic ductal adenocarcinoma (PDAC). USP21 overexpression correlates with human PDAC progression, and enforced expression of...

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Detalles Bibliográficos
Autores principales: Hou, Pingping, Ma, Xingdi, Zhang, Qiang, Wu, Chang-Jiun, Liao, Wenting, Li, Jun, Wang, Huamin, Zhao, Jun, Zhou, Xin, Guan, Carolyn, Ackroyd, Jeffery, Jiang, Shan, Zhang, Jianhua, Spring, Denise J., Wang, Y. Alan, DePinho, Ronald A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771391/
https://www.ncbi.nlm.nih.gov/pubmed/31488580
http://dx.doi.org/10.1101/gad.326314.119

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