The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A

How individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in humans and other animals are strongly biased to light (L)-strand non-CpG me...

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Detalles Bibliográficos
Autores principales: Dou, Xiaoyang, Boyd-Kirkup, Jerome D., McDermott, Joseph, Zhang, Xiaoli, Li, Fang, Rong, Bowen, Zhang, Rui, Miao, Bisi, Chen, Peilin, Cheng, Hao, Xue, Jianhuang, Bennett, David, Wong, Jiemin, Lan, Fei, Han, Jing-Dong J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771398/
https://www.ncbi.nlm.nih.gov/pubmed/31537639
http://dx.doi.org/10.1101/gr.234021.117

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