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Metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know

Chordoma is a rare tumor. It has unique clinical, pathological and immunohistochemical characteristics. Accurate diagnosis is essential as the tumor shows an aggressive clinical course and requires a multimodal therapeutic approach. A case with wide spread distant metastatic disease that was initial...

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Detalles Bibliográficos
Autores principales: Jaber, Omar I., Ashhab, Maxim Al
Formato: Online Artículo Texto
Lenguaje:English
Publicado: São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771453/
https://www.ncbi.nlm.nih.gov/pubmed/31641661
http://dx.doi.org/10.4322/acr.2019.120
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author Jaber, Omar I.
Ashhab, Maxim Al
author_facet Jaber, Omar I.
Ashhab, Maxim Al
author_sort Jaber, Omar I.
collection PubMed
description Chordoma is a rare tumor. It has unique clinical, pathological and immunohistochemical characteristics. Accurate diagnosis is essential as the tumor shows an aggressive clinical course and requires a multimodal therapeutic approach. A case with wide spread distant metastatic disease that was initially thought to represent metastatic thyroid carcinoma is presented. Appropriate clincopathologic correlation and the histologic findings raised the possibility of poorly differentiated chordoma. The diagnosis was confirmed by immunohistochemistry for INI-1 and Brachyury. The approach to the diagnosis emphasizing the clinical and pathologic findings of this case is discussed and reviewed in the context of the published literature.
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spelling pubmed-67714532019-10-22 Metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know Jaber, Omar I. Ashhab, Maxim Al Autops Case Rep Article / Clinical Case Report Chordoma is a rare tumor. It has unique clinical, pathological and immunohistochemical characteristics. Accurate diagnosis is essential as the tumor shows an aggressive clinical course and requires a multimodal therapeutic approach. A case with wide spread distant metastatic disease that was initially thought to represent metastatic thyroid carcinoma is presented. Appropriate clincopathologic correlation and the histologic findings raised the possibility of poorly differentiated chordoma. The diagnosis was confirmed by immunohistochemistry for INI-1 and Brachyury. The approach to the diagnosis emphasizing the clinical and pathologic findings of this case is discussed and reviewed in the context of the published literature. São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2019-09-27 /pmc/articles/PMC6771453/ /pubmed/31641661 http://dx.doi.org/10.4322/acr.2019.120 Text en Autopsy and Case Reports. ISSN 2236-1960. Copyright © 2019. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the article is properly cited.
spellingShingle Article / Clinical Case Report
Jaber, Omar I.
Ashhab, Maxim Al
Metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know
title Metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know
title_full Metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know
title_fullStr Metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know
title_full_unstemmed Metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know
title_short Metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know
title_sort metastatic poorly differentiated chordoma: the eyes do not see what the mind does not know
topic Article / Clinical Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771453/
https://www.ncbi.nlm.nih.gov/pubmed/31641661
http://dx.doi.org/10.4322/acr.2019.120
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