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Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development

Herpes simplex virus (HSV) can cause oral or genital ulcerative lesions and even encephalitis in various age groups with high infection rates. More seriously, HSV may lead to a wide range of recurrent diseases throughout a lifetime. No vaccines against HSV are currently available. The accumulated cl...

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Detalles Bibliográficos
Autores principales: Xu, Xingli, Zhang, Ying, Li, Qihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771534/
https://www.ncbi.nlm.nih.gov/pubmed/31197909
http://dx.doi.org/10.1002/rmv.2054
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author Xu, Xingli
Zhang, Ying
Li, Qihan
author_facet Xu, Xingli
Zhang, Ying
Li, Qihan
author_sort Xu, Xingli
collection PubMed
description Herpes simplex virus (HSV) can cause oral or genital ulcerative lesions and even encephalitis in various age groups with high infection rates. More seriously, HSV may lead to a wide range of recurrent diseases throughout a lifetime. No vaccines against HSV are currently available. The accumulated clinical research data for HSV vaccines reveal that the effects of HSV interacting with the host, especially the host immune system, may be important for the development of HSV vaccines. HSV vaccine development remains a major challenge. Thus, we focus on the research data regarding the interactions of HSV and host immune cells, including dendritic cells (DCs), innate lymphoid cells (ILCs), macrophages, and natural killer (NK) cells, and the related signal transduction pathways involved in immune evasion and cytokine production. The aim is to explore possible strategies to develop new effective HSV vaccines.
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spelling pubmed-67715342019-10-03 Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development Xu, Xingli Zhang, Ying Li, Qihan Rev Med Virol Reviews Herpes simplex virus (HSV) can cause oral or genital ulcerative lesions and even encephalitis in various age groups with high infection rates. More seriously, HSV may lead to a wide range of recurrent diseases throughout a lifetime. No vaccines against HSV are currently available. The accumulated clinical research data for HSV vaccines reveal that the effects of HSV interacting with the host, especially the host immune system, may be important for the development of HSV vaccines. HSV vaccine development remains a major challenge. Thus, we focus on the research data regarding the interactions of HSV and host immune cells, including dendritic cells (DCs), innate lymphoid cells (ILCs), macrophages, and natural killer (NK) cells, and the related signal transduction pathways involved in immune evasion and cytokine production. The aim is to explore possible strategies to develop new effective HSV vaccines. John Wiley and Sons Inc. 2019-06-13 2019-07 /pmc/articles/PMC6771534/ /pubmed/31197909 http://dx.doi.org/10.1002/rmv.2054 Text en © 2019 The Authors. Reviews in Medical Virology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Reviews
Xu, Xingli
Zhang, Ying
Li, Qihan
Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
title Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
title_full Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
title_fullStr Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
title_full_unstemmed Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
title_short Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
title_sort characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771534/
https://www.ncbi.nlm.nih.gov/pubmed/31197909
http://dx.doi.org/10.1002/rmv.2054
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