The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis

Aberrant expression of long noncoding RNAs (lncRNAs) contributes to all phenotypes of cancer including metastasis, which is a major cause of death in many advanced malignancies. One particular lncRNA, H19, is found to be a crucial player in cancer progression by modulating multiple microRNAs (miRNAs...

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Autores principales: Xu, YouZu, Lin, Jian, Jin, YingYing, Chen, Meifang, Zheng, HaiHong, Feng, JiaXi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771643/
https://www.ncbi.nlm.nih.gov/pubmed/31131469
http://dx.doi.org/10.1002/jcb.29006
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author Xu, YouZu
Lin, Jian
Jin, YingYing
Chen, Meifang
Zheng, HaiHong
Feng, JiaXi
author_facet Xu, YouZu
Lin, Jian
Jin, YingYing
Chen, Meifang
Zheng, HaiHong
Feng, JiaXi
author_sort Xu, YouZu
collection PubMed
description Aberrant expression of long noncoding RNAs (lncRNAs) contributes to all phenotypes of cancer including metastasis, which is a major cause of death in many advanced malignancies. One particular lncRNA, H19, is found to be a crucial player in cancer progression by modulating multiple microRNAs (miRNAs). In this study, we screened miRNAs possibly associated with H19 using lung carcinoma cell lines and patient with lung cancer tissues, and selected one possible hit, hsa‐miR‐6515‐3p, to perform in vitro functional assays. Its inhibition leads to decreased proliferation and migration of SPC‐A1 lung cancer cells and is in good correlation with H19‐knockdown groups. These results indicate that H19 may be an epigenetic regulator of miR‐6515‐3p, and its dysregulation may contribute to lung cancer progression and metastasis.
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spelling pubmed-67716432019-10-03 The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis Xu, YouZu Lin, Jian Jin, YingYing Chen, Meifang Zheng, HaiHong Feng, JiaXi J Cell Biochem Research Articles Aberrant expression of long noncoding RNAs (lncRNAs) contributes to all phenotypes of cancer including metastasis, which is a major cause of death in many advanced malignancies. One particular lncRNA, H19, is found to be a crucial player in cancer progression by modulating multiple microRNAs (miRNAs). In this study, we screened miRNAs possibly associated with H19 using lung carcinoma cell lines and patient with lung cancer tissues, and selected one possible hit, hsa‐miR‐6515‐3p, to perform in vitro functional assays. Its inhibition leads to decreased proliferation and migration of SPC‐A1 lung cancer cells and is in good correlation with H19‐knockdown groups. These results indicate that H19 may be an epigenetic regulator of miR‐6515‐3p, and its dysregulation may contribute to lung cancer progression and metastasis. John Wiley and Sons Inc. 2019-05-26 2019-10 /pmc/articles/PMC6771643/ /pubmed/31131469 http://dx.doi.org/10.1002/jcb.29006 Text en © 2019 The Authors. Journal of Cellular Biochemistry Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Xu, YouZu
Lin, Jian
Jin, YingYing
Chen, Meifang
Zheng, HaiHong
Feng, JiaXi
The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis
title The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis
title_full The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis
title_fullStr The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis
title_full_unstemmed The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis
title_short The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis
title_sort mirna hsa‐mir‐6515‐3p potentially contributes to lncrna h19‐mediated‐lung cancer metastasis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771643/
https://www.ncbi.nlm.nih.gov/pubmed/31131469
http://dx.doi.org/10.1002/jcb.29006
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