Exendin‐4 analogs in insulinoma theranostics

Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon‐like peptide‐1 receptor. Therefore, imaging with glucagon‐like peptide analog exendin‐4 can be used for diagnosis and preoperative localization. This review presents an overview of the de...

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Autores principales: Jansen, Tom.J.P., van Lith, Sanne.A.M., Boss, Marti, Brom, Maarten, Joosten, Lieke, Béhé, Martin, Buitinga, Mijke, Gotthardt, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Special Issue Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771680/
https://www.ncbi.nlm.nih.gov/pubmed/31070270
http://dx.doi.org/10.1002/jlcr.3750
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author Jansen, Tom.J.P.
van Lith, Sanne.A.M.
Boss, Marti
Brom, Maarten
Joosten, Lieke
Béhé, Martin
Buitinga, Mijke
Gotthardt, Martin
author_facet Jansen, Tom.J.P.
van Lith, Sanne.A.M.
Boss, Marti
Brom, Maarten
Joosten, Lieke
Béhé, Martin
Buitinga, Mijke
Gotthardt, Martin
author_sort Jansen, Tom.J.P.
collection PubMed
description Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon‐like peptide‐1 receptor. Therefore, imaging with glucagon‐like peptide analog exendin‐4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin‐based tracers for nuclear imaging, and the potential use of exendin‐4 based tracers for optical imaging and therapeutic applications such as peptide receptor radionuclide therapy or targeted photodynamic therapy. [Image: see text]
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spelling pubmed-67716802019-10-07 Exendin‐4 analogs in insulinoma theranostics Jansen, Tom.J.P. van Lith, Sanne.A.M. Boss, Marti Brom, Maarten Joosten, Lieke Béhé, Martin Buitinga, Mijke Gotthardt, Martin J Labelled Comp Radiopharm Special Issue Review Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon‐like peptide‐1 receptor. Therefore, imaging with glucagon‐like peptide analog exendin‐4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin‐based tracers for nuclear imaging, and the potential use of exendin‐4 based tracers for optical imaging and therapeutic applications such as peptide receptor radionuclide therapy or targeted photodynamic therapy. [Image: see text] John Wiley and Sons Inc. 2019-08-28 2019-08 /pmc/articles/PMC6771680/ /pubmed/31070270 http://dx.doi.org/10.1002/jlcr.3750 Text en © 2019 The Authors Journal of Labelled Compounds and Radiopharmaceuticals Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Special Issue Review
Jansen, Tom.J.P.
van Lith, Sanne.A.M.
Boss, Marti
Brom, Maarten
Joosten, Lieke
Béhé, Martin
Buitinga, Mijke
Gotthardt, Martin
Exendin‐4 analogs in insulinoma theranostics
title Exendin‐4 analogs in insulinoma theranostics
title_full Exendin‐4 analogs in insulinoma theranostics
title_fullStr Exendin‐4 analogs in insulinoma theranostics
title_full_unstemmed Exendin‐4 analogs in insulinoma theranostics
title_short Exendin‐4 analogs in insulinoma theranostics
title_sort exendin‐4 analogs in insulinoma theranostics
topic Special Issue Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771680/
https://www.ncbi.nlm.nih.gov/pubmed/31070270
http://dx.doi.org/10.1002/jlcr.3750
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