Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals Tailoring Strategy for Nonribosomal Peptide Backbones

Thioamide‐containing nonribosomal peptides (NRPs) are exceedingly rare. Recently the biosynthetic gene cluster for the thioamidated NRP antibiotic closthioamide (CTA) was reported, however, the enzyme responsible for and the timing of thioamide formation remained enigmatic. Here, genome editing, bio...

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Detalles Bibliográficos
Autores principales: Dunbar, Kyle L., Dell, Maria, Molloy, Evelyn M., Kloss, Florian, Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772006/
https://www.ncbi.nlm.nih.gov/pubmed/31276268
http://dx.doi.org/10.1002/anie.201905992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772006/
https://www.ncbi.nlm.nih.gov/pubmed/31276268
http://dx.doi.org/10.1002/anie.201905992

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