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Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind
Canonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor 1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan development and tissue renewal. Although much evidence has associated canonical Wnt/β‐catenin signaling with mood disorders,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772062/ https://www.ncbi.nlm.nih.gov/pubmed/31218672 http://dx.doi.org/10.1002/1873-3468.13502 |
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author | Bem, Joanna Brożko, Nikola Chakraborty, Chaitali Lipiec, Marcin A. Koziński, Kamil Nagalski, Andrzej Szewczyk, Łukasz M. Wiśniewska, Marta B. |
author_facet | Bem, Joanna Brożko, Nikola Chakraborty, Chaitali Lipiec, Marcin A. Koziński, Kamil Nagalski, Andrzej Szewczyk, Łukasz M. Wiśniewska, Marta B. |
author_sort | Bem, Joanna |
collection | PubMed |
description | Canonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor 1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan development and tissue renewal. Although much evidence has associated canonical Wnt/β‐catenin signaling with mood disorders, the mechanistic links are still unknown. Many components of the canonical Wnt pathway are involved in cellular processes that are unrelated to classical canonical Wnt signaling, thus further blurring the picture. The present review critically evaluates the involvement of classical Wnt/β‐catenin signaling in developmental processes that putatively underlie the pathology of mental illnesses. Particular attention is given to the roles of LEF1/TCFs, which have been discussed surprisingly rarely in this context. Highlighting recent discoveries, we propose that alterations in the activity of LEF1/TCFs, and particularly of transcription factor 7‐like 2 (TCF7L2), result in defects previously associated with neuropsychiatric disorders, including imbalances in neurogenesis and oligodendrogenesis, the functional disruption of thalamocortical circuitry and dysfunction of the habenula. |
format | Online Article Text |
id | pubmed-6772062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67720622019-10-07 Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind Bem, Joanna Brożko, Nikola Chakraborty, Chaitali Lipiec, Marcin A. Koziński, Kamil Nagalski, Andrzej Szewczyk, Łukasz M. Wiśniewska, Marta B. FEBS Lett Review Article Canonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor 1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan development and tissue renewal. Although much evidence has associated canonical Wnt/β‐catenin signaling with mood disorders, the mechanistic links are still unknown. Many components of the canonical Wnt pathway are involved in cellular processes that are unrelated to classical canonical Wnt signaling, thus further blurring the picture. The present review critically evaluates the involvement of classical Wnt/β‐catenin signaling in developmental processes that putatively underlie the pathology of mental illnesses. Particular attention is given to the roles of LEF1/TCFs, which have been discussed surprisingly rarely in this context. Highlighting recent discoveries, we propose that alterations in the activity of LEF1/TCFs, and particularly of transcription factor 7‐like 2 (TCF7L2), result in defects previously associated with neuropsychiatric disorders, including imbalances in neurogenesis and oligodendrogenesis, the functional disruption of thalamocortical circuitry and dysfunction of the habenula. John Wiley and Sons Inc. 2019-06-30 2019-07 /pmc/articles/PMC6772062/ /pubmed/31218672 http://dx.doi.org/10.1002/1873-3468.13502 Text en © 2019 The Authors FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bem, Joanna Brożko, Nikola Chakraborty, Chaitali Lipiec, Marcin A. Koziński, Kamil Nagalski, Andrzej Szewczyk, Łukasz M. Wiśniewska, Marta B. Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind |
title | Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind |
title_full | Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind |
title_fullStr | Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind |
title_full_unstemmed | Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind |
title_short | Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind |
title_sort | wnt/β‐catenin signaling in brain development and mental disorders: keeping tcf7l2 in mind |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772062/ https://www.ncbi.nlm.nih.gov/pubmed/31218672 http://dx.doi.org/10.1002/1873-3468.13502 |
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