Structure and Energetics of Ligand–Fluorine Interactions with Galectin‐3 Backbone and Side‐Chain Amides: Insight into Solvation Effects and Multipolar Interactions

Multipolar fluorine–amide interactions with backbone and side‐chain amides have been described as important for protein–ligand interactions and have been used to improve the potency of synthetic inhibitors. In this study, fluorine interactions within a well‐defined binding pocket on galectin‐3 were...

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Detalles Bibliográficos
Autores principales: Kumar, Rohit, Ignjatović, Majda Misini, Peterson, Kristoffer, Olsson, Martin, Leffler, Hakon, Ryde, Ulf, Nilsson, Ulf J., Logan, Derek T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772088/
https://www.ncbi.nlm.nih.gov/pubmed/31246331
http://dx.doi.org/10.1002/cmdc.201900293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772088/
https://www.ncbi.nlm.nih.gov/pubmed/31246331
http://dx.doi.org/10.1002/cmdc.201900293

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