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Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations
A dense hydrogen‐bond network is responsible for the mechanical and structural properties of polysaccharides. Random derivatization alters the properties of the bulk material by disrupting the hydrogen bonds, but obstructs detailed structure–function correlations. We have prepared well‐defined unnat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772130/ https://www.ncbi.nlm.nih.gov/pubmed/31359577 http://dx.doi.org/10.1002/anie.201906577 |
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author | Yu, Yang Tyrikos‐Ergas, Theodore Zhu, Yuntao Fittolani, Giulio Bordoni, Vittorio Singhal, Ankush Fair, Richard J. Grafmüller, Andrea Seeberger, Peter H. Delbianco, Martina |
author_facet | Yu, Yang Tyrikos‐Ergas, Theodore Zhu, Yuntao Fittolani, Giulio Bordoni, Vittorio Singhal, Ankush Fair, Richard J. Grafmüller, Andrea Seeberger, Peter H. Delbianco, Martina |
author_sort | Yu, Yang |
collection | PubMed |
description | A dense hydrogen‐bond network is responsible for the mechanical and structural properties of polysaccharides. Random derivatization alters the properties of the bulk material by disrupting the hydrogen bonds, but obstructs detailed structure–function correlations. We have prepared well‐defined unnatural oligosaccharides including methylated, deoxygenated, deoxyfluorinated, as well as carboxymethylated cellulose and chitin analogues with full control over the degree and pattern of substitution. Molecular dynamics simulations and crystallographic analysis show how distinct hydrogen‐bond modifications drastically affect the solubility, aggregation behavior, and crystallinity of carbohydrate materials. This systematic approach to establishing detailed structure–property correlations will guide the synthesis of novel, tailor‐made carbohydrate materials. |
format | Online Article Text |
id | pubmed-6772130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67721302019-10-07 Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations Yu, Yang Tyrikos‐Ergas, Theodore Zhu, Yuntao Fittolani, Giulio Bordoni, Vittorio Singhal, Ankush Fair, Richard J. Grafmüller, Andrea Seeberger, Peter H. Delbianco, Martina Angew Chem Int Ed Engl Research Articles A dense hydrogen‐bond network is responsible for the mechanical and structural properties of polysaccharides. Random derivatization alters the properties of the bulk material by disrupting the hydrogen bonds, but obstructs detailed structure–function correlations. We have prepared well‐defined unnatural oligosaccharides including methylated, deoxygenated, deoxyfluorinated, as well as carboxymethylated cellulose and chitin analogues with full control over the degree and pattern of substitution. Molecular dynamics simulations and crystallographic analysis show how distinct hydrogen‐bond modifications drastically affect the solubility, aggregation behavior, and crystallinity of carbohydrate materials. This systematic approach to establishing detailed structure–property correlations will guide the synthesis of novel, tailor‐made carbohydrate materials. John Wiley and Sons Inc. 2019-08-19 2019-09-09 /pmc/articles/PMC6772130/ /pubmed/31359577 http://dx.doi.org/10.1002/anie.201906577 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Yu, Yang Tyrikos‐Ergas, Theodore Zhu, Yuntao Fittolani, Giulio Bordoni, Vittorio Singhal, Ankush Fair, Richard J. Grafmüller, Andrea Seeberger, Peter H. Delbianco, Martina Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations |
title | Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations |
title_full | Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations |
title_fullStr | Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations |
title_full_unstemmed | Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations |
title_short | Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations |
title_sort | systematic hydrogen‐bond manipulations to establish polysaccharide structure–property correlations |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772130/ https://www.ncbi.nlm.nih.gov/pubmed/31359577 http://dx.doi.org/10.1002/anie.201906577 |
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