Confirmation that somatic mutations of beta‐2 microglobulin correlate with a lack of recurrence in a subset of stage II mismatch repair deficient colorectal cancers from the QUASAR trial

AIMS: Beta2‐microglobulin (B2M) forms part of the HLA class I complex and plays a role in metastatic biology. B2M mutations occur frequently in mismatch repair‐deficient colorectal cancer (dMMR CRC), with limited data suggesting they may protect against recurrence. Our experimental study tested this...

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Detalles Bibliográficos
Autores principales: Barrow, Paul, Richman, Susan D, Wallace, Andrew J, Handley, Kelly, Hutchins, Gordon G A, Kerr, David, Magill, Laura, Evans, D Gareth, Gray, Richard, Quirke, Phil, Hill, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772160/
https://www.ncbi.nlm.nih.gov/pubmed/31062389
http://dx.doi.org/10.1111/his.13895

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