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A comparison of subgroup identification methods in clinical drug development: Simulation study and regulatory considerations
With advancement of technologies such as genomic sequencing, predictive biomarkers have become a useful tool for the development of personalized medicine. Predictive biomarkers can be used to select subsets of patients, which are most likely to benefit from a treatment. A number of approaches for su...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772173/ https://www.ncbi.nlm.nih.gov/pubmed/31270933 http://dx.doi.org/10.1002/pst.1951 |