Site‐Selective, Remote sp(3) C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis

A photoinduced carboxylation of alkyl halides with CO(2) at remote sp(3) C−H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rat...

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Autores principales: Sahoo, Basudev, Bellotti, Peter, Juliá‐Hernández, Francisco, Meng, Qing‐Yuan, Crespi, Stefano, König, Burkhard, Martin, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773098/
https://www.ncbi.nlm.nih.gov/pubmed/31074058
http://dx.doi.org/10.1002/chem.201902095
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author Sahoo, Basudev
Bellotti, Peter
Juliá‐Hernández, Francisco
Meng, Qing‐Yuan
Crespi, Stefano
König, Burkhard
Martin, Ruben
author_facet Sahoo, Basudev
Bellotti, Peter
Juliá‐Hernández, Francisco
Meng, Qing‐Yuan
Crespi, Stefano
König, Burkhard
Martin, Ruben
author_sort Sahoo, Basudev
collection PubMed
description A photoinduced carboxylation of alkyl halides with CO(2) at remote sp(3) C−H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.
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spelling pubmed-67730982019-10-07 Site‐Selective, Remote sp(3) C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis Sahoo, Basudev Bellotti, Peter Juliá‐Hernández, Francisco Meng, Qing‐Yuan Crespi, Stefano König, Burkhard Martin, Ruben Chemistry Communications A photoinduced carboxylation of alkyl halides with CO(2) at remote sp(3) C−H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain. John Wiley and Sons Inc. 2019-06-06 2019-07-05 /pmc/articles/PMC6773098/ /pubmed/31074058 http://dx.doi.org/10.1002/chem.201902095 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Sahoo, Basudev
Bellotti, Peter
Juliá‐Hernández, Francisco
Meng, Qing‐Yuan
Crespi, Stefano
König, Burkhard
Martin, Ruben
Site‐Selective, Remote sp(3) C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
title Site‐Selective, Remote sp(3) C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
title_full Site‐Selective, Remote sp(3) C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
title_fullStr Site‐Selective, Remote sp(3) C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
title_full_unstemmed Site‐Selective, Remote sp(3) C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
title_short Site‐Selective, Remote sp(3) C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
title_sort site‐selective, remote sp(3) c−h carboxylation enabled by the merger of photoredox and nickel catalysis
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773098/
https://www.ncbi.nlm.nih.gov/pubmed/31074058
http://dx.doi.org/10.1002/chem.201902095
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