EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia

EZH2 is overexpressed in poor-prognostic chronic lymphocytic leukaemia (CLL) cases, acting as an oncogene; however, thus far, the EZH2 target genes in CLL have not been disclosed. In this study, using ChIP-sequencing, we identified EZH2 and H3K27me3 target genes in two prognostic subgroups of CLL wi...

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Detalles Bibliográficos
Autores principales: Kosalai, Subazini Thankaswamy, Morsy, Mohammad Hamdy Abdelrazak, Papakonstantinou, Nikos, Mansouri, Larry, Stavroyianni, Niki, Kanduri, Chandrasekhar, Stamatopoulos, Kostas, Rosenquist, Richard, Kanduri, Meena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773411/
https://www.ncbi.nlm.nih.gov/pubmed/31216925
http://dx.doi.org/10.1080/15592294.2019.1633867

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