MRGPRX4 is a bile acid receptor for human cholestatic itch

Patients with liver diseases often suffer from chronic itch, yet the pruritogen(s) and receptor(s) remain largely elusive. Here, we identify bile acids as natural ligands for MRGPRX4. MRGPRX4 is expressed in human dorsal root ganglion (hDRG) neurons and co-expresses with itch receptor HRH1. Bile aci...

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Detalles Bibliográficos
Autores principales: Yu, Huasheng, Zhao, Tianjun, Liu, Simin, Wu, Qinxue, Johnson, Omar, Wu, Zhaofa, Zhuang, Zihao, Shi, Yaocheng, Peng, Luxin, He, Renxi, Yang, Yong, Sun, Jianjun, Wang, Xiaoqun, Xu, Haifeng, Zeng, Zheng, Zou, Peng, Lei, Xiaoguang, Luo, Wenqin, Li, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773440/
https://www.ncbi.nlm.nih.gov/pubmed/31500698
http://dx.doi.org/10.7554/eLife.48431

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