A case series of the dynamics of lipid mediators in patients with sepsis

BACKGROUND: Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls. CASE PRESENTATION: Four patients with a Sequential Organ Failure Assessment (SOFA) score of <7 recovered from...

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Autores principales: Hamaguchi, Mitsuhide, Wu, Heng Ning, Tanaka, Masahiro, Tsuda, Noriko, Tantengco, Ourlad Alzeus Gaddi, Matsushima, Tomohide, Nakao, Takami, Ishibe, Takuya, Sakata, Ikuhiro, Yanagihara, Itaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773642/
https://www.ncbi.nlm.nih.gov/pubmed/31592324
http://dx.doi.org/10.1002/ams2.443
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author Hamaguchi, Mitsuhide
Wu, Heng Ning
Tanaka, Masahiro
Tsuda, Noriko
Tantengco, Ourlad Alzeus Gaddi
Matsushima, Tomohide
Nakao, Takami
Ishibe, Takuya
Sakata, Ikuhiro
Yanagihara, Itaru
author_facet Hamaguchi, Mitsuhide
Wu, Heng Ning
Tanaka, Masahiro
Tsuda, Noriko
Tantengco, Ourlad Alzeus Gaddi
Matsushima, Tomohide
Nakao, Takami
Ishibe, Takuya
Sakata, Ikuhiro
Yanagihara, Itaru
author_sort Hamaguchi, Mitsuhide
collection PubMed
description BACKGROUND: Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls. CASE PRESENTATION: Four patients with a Sequential Organ Failure Assessment (SOFA) score of <7 recovered from sepsis. One patient with SOFA score of 12 on day 7 died on day 21. In the fatal case, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, and linoleic acid‐derived lipid mediators, including 9‐hydroxyoctadecadienoic acid (9‐HODE), 13‐HODE, 9,10‐dihydroxy‐12‐octadecenoic acid (9,10‐DiHOME), and 12,13‐DiHOME, were elevated on day 1. Increase in anti‐inflammatory prostaglandin E(1) ethanolamide together with persistently lower transcription level of FAAH mRNA was detected on day 7 in the fatal case. CONCLUSION: Lipidomic analysis on day 1 revealed elevated linoleic acid metabolites, whereas on day 7, elevated prostaglandin E(1) ethanolamide and low level of FAAH mRNA transcription were observed in the fatal case of sepsis.
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spelling pubmed-67736422019-10-07 A case series of the dynamics of lipid mediators in patients with sepsis Hamaguchi, Mitsuhide Wu, Heng Ning Tanaka, Masahiro Tsuda, Noriko Tantengco, Ourlad Alzeus Gaddi Matsushima, Tomohide Nakao, Takami Ishibe, Takuya Sakata, Ikuhiro Yanagihara, Itaru Acute Med Surg Case Reports BACKGROUND: Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls. CASE PRESENTATION: Four patients with a Sequential Organ Failure Assessment (SOFA) score of <7 recovered from sepsis. One patient with SOFA score of 12 on day 7 died on day 21. In the fatal case, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, and linoleic acid‐derived lipid mediators, including 9‐hydroxyoctadecadienoic acid (9‐HODE), 13‐HODE, 9,10‐dihydroxy‐12‐octadecenoic acid (9,10‐DiHOME), and 12,13‐DiHOME, were elevated on day 1. Increase in anti‐inflammatory prostaglandin E(1) ethanolamide together with persistently lower transcription level of FAAH mRNA was detected on day 7 in the fatal case. CONCLUSION: Lipidomic analysis on day 1 revealed elevated linoleic acid metabolites, whereas on day 7, elevated prostaglandin E(1) ethanolamide and low level of FAAH mRNA transcription were observed in the fatal case of sepsis. John Wiley and Sons Inc. 2019-07-18 /pmc/articles/PMC6773642/ /pubmed/31592324 http://dx.doi.org/10.1002/ams2.443 Text en © 2019 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Hamaguchi, Mitsuhide
Wu, Heng Ning
Tanaka, Masahiro
Tsuda, Noriko
Tantengco, Ourlad Alzeus Gaddi
Matsushima, Tomohide
Nakao, Takami
Ishibe, Takuya
Sakata, Ikuhiro
Yanagihara, Itaru
A case series of the dynamics of lipid mediators in patients with sepsis
title A case series of the dynamics of lipid mediators in patients with sepsis
title_full A case series of the dynamics of lipid mediators in patients with sepsis
title_fullStr A case series of the dynamics of lipid mediators in patients with sepsis
title_full_unstemmed A case series of the dynamics of lipid mediators in patients with sepsis
title_short A case series of the dynamics of lipid mediators in patients with sepsis
title_sort case series of the dynamics of lipid mediators in patients with sepsis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773642/
https://www.ncbi.nlm.nih.gov/pubmed/31592324
http://dx.doi.org/10.1002/ams2.443
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