Cargando…
Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study
A higher frequency of early onset female breast cancers (BC) has been observed in low/middle income countries than in high income countries. We quantified the role of population ageing to this pattern using data from all population-based cancer registries (CRs) worldwide. Patients’ median age at BC...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773713/ https://www.ncbi.nlm.nih.gov/pubmed/31575963 http://dx.doi.org/10.1038/s41598-019-50680-5 |
_version_ | 1783455935035867136 |
---|---|
author | Bidoli, Ettore Virdone, Saverio Hamdi-Cherif, Mokhtar Toffolutti, Federica Taborelli, Martina Panato, Chiara Serraino, Diego |
author_facet | Bidoli, Ettore Virdone, Saverio Hamdi-Cherif, Mokhtar Toffolutti, Federica Taborelli, Martina Panato, Chiara Serraino, Diego |
author_sort | Bidoli, Ettore |
collection | PubMed |
description | A higher frequency of early onset female breast cancers (BC) has been observed in low/middle income countries than in high income countries. We quantified the role of population ageing to this pattern using data from all population-based cancer registries (CRs) worldwide. Patients’ median age at BC onset and that of the general population were extracted for CRs listed in volumes VI (1983–1987 years) through XI (2008–2012 years) of Cancer Incidence in Five Continents. Their association was assessed at cross-sectional level by linear regression model and longitudinally considering 25-year ageing of the population in long-standing CRs listed at the beginning and at the end of the study. During 2008–2012, each one-year increase of population ageing was associated with a nearly ½ year increase of age at BC diagnosis. Population demographics explained forty-two percent of the age variance for BC. In 1983–1987, long-standing CRs with a median age at BC below age 61.8 years showed an increase of age at BC after 25-years. Worldwide, age at BC diagnosis essentially reflected the median age of the population. Changes in BC detection methodology likely lessened this association. Nevertheless, the elevated absolute number of BCs in young populations deserves strategies of BC prevention. |
format | Online Article Text |
id | pubmed-6773713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67737132019-10-04 Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study Bidoli, Ettore Virdone, Saverio Hamdi-Cherif, Mokhtar Toffolutti, Federica Taborelli, Martina Panato, Chiara Serraino, Diego Sci Rep Article A higher frequency of early onset female breast cancers (BC) has been observed in low/middle income countries than in high income countries. We quantified the role of population ageing to this pattern using data from all population-based cancer registries (CRs) worldwide. Patients’ median age at BC onset and that of the general population were extracted for CRs listed in volumes VI (1983–1987 years) through XI (2008–2012 years) of Cancer Incidence in Five Continents. Their association was assessed at cross-sectional level by linear regression model and longitudinally considering 25-year ageing of the population in long-standing CRs listed at the beginning and at the end of the study. During 2008–2012, each one-year increase of population ageing was associated with a nearly ½ year increase of age at BC diagnosis. Population demographics explained forty-two percent of the age variance for BC. In 1983–1987, long-standing CRs with a median age at BC below age 61.8 years showed an increase of age at BC after 25-years. Worldwide, age at BC diagnosis essentially reflected the median age of the population. Changes in BC detection methodology likely lessened this association. Nevertheless, the elevated absolute number of BCs in young populations deserves strategies of BC prevention. Nature Publishing Group UK 2019-10-01 /pmc/articles/PMC6773713/ /pubmed/31575963 http://dx.doi.org/10.1038/s41598-019-50680-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bidoli, Ettore Virdone, Saverio Hamdi-Cherif, Mokhtar Toffolutti, Federica Taborelli, Martina Panato, Chiara Serraino, Diego Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study |
title | Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study |
title_full | Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study |
title_fullStr | Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study |
title_full_unstemmed | Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study |
title_short | Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study |
title_sort | worldwide age at onset of female breast cancer: a 25-year population-based cancer registry study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773713/ https://www.ncbi.nlm.nih.gov/pubmed/31575963 http://dx.doi.org/10.1038/s41598-019-50680-5 |
work_keys_str_mv | AT bidoliettore worldwideageatonsetoffemalebreastcancera25yearpopulationbasedcancerregistrystudy AT virdonesaverio worldwideageatonsetoffemalebreastcancera25yearpopulationbasedcancerregistrystudy AT hamdicherifmokhtar worldwideageatonsetoffemalebreastcancera25yearpopulationbasedcancerregistrystudy AT toffoluttifederica worldwideageatonsetoffemalebreastcancera25yearpopulationbasedcancerregistrystudy AT taborellimartina worldwideageatonsetoffemalebreastcancera25yearpopulationbasedcancerregistrystudy AT panatochiara worldwideageatonsetoffemalebreastcancera25yearpopulationbasedcancerregistrystudy AT serrainodiego worldwideageatonsetoffemalebreastcancera25yearpopulationbasedcancerregistrystudy |