Paradoxical epigenetic regulation of XAF1 mediates plasticity towards adaptive resistance evolution in MGMT-methylated glioblastoma

Epigenetic regulation of O(6)-alkylguanine DNA alkyltransferase (MGMT) is surrogate of intrinsic resistance to temozolomide (TMZ). However, mechanisms associated with adaptive resistance evolution of glioblastoma (GBM) relative to MGMT methylation remain unclear. We hereby report a paradoxical yet t...

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Detalles Bibliográficos
Autores principales: Wu, Qiong, Berglund, Anders E., Wang, Dapeng, MacAulay, Robert J., Mulé, James J., Etame, Arnold B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773736/
https://www.ncbi.nlm.nih.gov/pubmed/31575897
http://dx.doi.org/10.1038/s41598-019-50489-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773736/
https://www.ncbi.nlm.nih.gov/pubmed/31575897
http://dx.doi.org/10.1038/s41598-019-50489-2

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