Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons resulting in severe neurological symptoms. Previous findings of our lab suggested that the axonal guidance tyrosine-kinase receptor EphA4 is an ALS disease-modifying gene. Reduction of EphA4 from developmen...

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Detalles Bibliográficos
Autores principales: Rué, Laura, Timmers, Mieke, Lenaerts, Annette, Smolders, Silke, Poppe, Lindsay, de Boer, Antina, Van Den Bosch, Ludo, Van Damme, Philip, Robberecht, Wim, Lemmens, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773754/
https://www.ncbi.nlm.nih.gov/pubmed/31575928
http://dx.doi.org/10.1038/s41598-019-50615-0

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