Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3/TEF gene fusion

The TCF3/PBX1 gene fusion is a recurrent genetic abnormality in pediatric B-lymphoblastic leukemia/lymphoma (B-ALL/LBL). While dual-color, dual-fusion fluorescence in situ hybridization (D-FISH) probes can detect TCF3/PBX1 fusions, further characterization of atypical TCF3 FISH patterns as indicated...

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Detalles Bibliográficos
Autores principales: Rowsey, Ross A., Smoley, Stephanie A., Williamson, Cynthia M., Vasmatzis, George, Smadbeck, James B., Ning, Yi, Greipp, Patricia T., Hoppman, Nicole L., Baughn, Linda B., Ketterling, Rhett P., Peterson, Jess F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773761/
https://www.ncbi.nlm.nih.gov/pubmed/31575852
http://dx.doi.org/10.1038/s41408-019-0239-z

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