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Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation
Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms. Here, we describe a 69-year-old patient who developed anti-NMDA receptor encephalitis while being under adequate immunosuppressive therapy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773799/ https://www.ncbi.nlm.nih.gov/pubmed/31608003 http://dx.doi.org/10.3389/fneur.2019.00987 |
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author | Konen, Franz Felix Schwenkenbecher, Philipp Jendretzky, Konstantin Fritz Hümmert, Martin Werner Wegner, Florian Stangel, Martin Sühs, Kurt-Wolfram Skripuletz, Thomas |
author_facet | Konen, Franz Felix Schwenkenbecher, Philipp Jendretzky, Konstantin Fritz Hümmert, Martin Werner Wegner, Florian Stangel, Martin Sühs, Kurt-Wolfram Skripuletz, Thomas |
author_sort | Konen, Franz Felix |
collection | PubMed |
description | Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms. Here, we describe a 69-year-old patient who developed anti-NMDA receptor encephalitis while being under adequate immunosuppressive therapy following liver transplantation. Although a broad spectrum of different immunotherapies was applied and anti-NMDA receptor antibody titers gradually decreased, the clinical course could not be affected positively. Autoimmune encephalitis after transplantation is only described in a few cases and not well-recognized. Our case adds further evidence for anti-NMDA receptor encephalitis as the cause of neuropsychiatric symptoms even under immunosuppressive therapy in a post-transplant setting. |
format | Online Article Text |
id | pubmed-6773799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67737992019-10-13 Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation Konen, Franz Felix Schwenkenbecher, Philipp Jendretzky, Konstantin Fritz Hümmert, Martin Werner Wegner, Florian Stangel, Martin Sühs, Kurt-Wolfram Skripuletz, Thomas Front Neurol Neurology Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms. Here, we describe a 69-year-old patient who developed anti-NMDA receptor encephalitis while being under adequate immunosuppressive therapy following liver transplantation. Although a broad spectrum of different immunotherapies was applied and anti-NMDA receptor antibody titers gradually decreased, the clinical course could not be affected positively. Autoimmune encephalitis after transplantation is only described in a few cases and not well-recognized. Our case adds further evidence for anti-NMDA receptor encephalitis as the cause of neuropsychiatric symptoms even under immunosuppressive therapy in a post-transplant setting. Frontiers Media S.A. 2019-09-25 /pmc/articles/PMC6773799/ /pubmed/31608003 http://dx.doi.org/10.3389/fneur.2019.00987 Text en Copyright © 2019 Konen, Schwenkenbecher, Jendretzky, Hümmert, Wegner, Stangel, Sühs and Skripuletz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Konen, Franz Felix Schwenkenbecher, Philipp Jendretzky, Konstantin Fritz Hümmert, Martin Werner Wegner, Florian Stangel, Martin Sühs, Kurt-Wolfram Skripuletz, Thomas Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
title | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
title_full | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
title_fullStr | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
title_full_unstemmed | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
title_short | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
title_sort | severe anti-n-methyl-d-aspartate receptor encephalitis under immunosuppression after liver transplantation |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773799/ https://www.ncbi.nlm.nih.gov/pubmed/31608003 http://dx.doi.org/10.3389/fneur.2019.00987 |
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