Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

V565 is an engineered TNFα-neutralising single domain antibody formulated into enteric coated mini-tablets to enable release in the intestine after oral administration as a possible oral treatment for inflammatory bowel disease (IBD). Following oral administration, ileal recovery of V565 was investi...

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Detalles Bibliográficos
Autores principales: Nurbhai, Suhail, Roberts, Kevin J., Carlton, Timothy M., Maggiore, Luana, Cubitt, Marion F., Ray, Keith P., Reckless, Jill, Mohammed, Hafeez, Irving, Peter, MacDonald, Thomas T., Vossenkämper, Anna, West, Michael R., Parkes, Gareth C., Crowe, J. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773840/
https://www.ncbi.nlm.nih.gov/pubmed/31575982
http://dx.doi.org/10.1038/s41598-019-50545-x

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