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Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids
8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly controlled carbocationic chemistry of this sesq...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774066/ https://www.ncbi.nlm.nih.gov/pubmed/31598175 http://dx.doi.org/10.3762/bjoc.15.215 |
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| author | Demiray, Melodi Miller, David J Allemann, Rudolf K |
| author_facet | Demiray, Melodi Miller, David J Allemann, Rudolf K |
| author_sort | Demiray, Melodi |
| collection | PubMed |
| description | 8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly controlled carbocationic chemistry of this sesquiterpene cyclase. |
| format | Online Article Text |
| id | pubmed-6774066 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Beilstein-Institut |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67740662019-10-09 Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids Demiray, Melodi Miller, David J Allemann, Rudolf K Beilstein J Org Chem Full Research Paper 8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly controlled carbocationic chemistry of this sesquiterpene cyclase. Beilstein-Institut 2019-09-17 /pmc/articles/PMC6774066/ /pubmed/31598175 http://dx.doi.org/10.3762/bjoc.15.215 Text en Copyright © 2019, Demiray et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
| spellingShingle | Full Research Paper Demiray, Melodi Miller, David J Allemann, Rudolf K Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids |
| title | Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids |
| title_full | Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids |
| title_fullStr | Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids |
| title_full_unstemmed | Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids |
| title_short | Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids |
| title_sort | harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids |
| topic | Full Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774066/ https://www.ncbi.nlm.nih.gov/pubmed/31598175 http://dx.doi.org/10.3762/bjoc.15.215 |
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