Cargando…

The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study

BACKGROUND: Being obese or underweight, and having diabetes are important risk factors for new-onset atrial fibrillation (AF). However, it is unclear whether there is any interaction between body weight and diabetes in regard to development of new-onset AF. We aimed to evaluate the role of body weig...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yun Gi, Han, Kyung-Do, Choi, Jong-Il, Boo, Ki Yung, Kim, Do Young, Oh, Suk-Kyu, Lee, Kwang-No, Shim, Jaemin, Kim, Jin Seok, Kim, Young-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774211/
https://www.ncbi.nlm.nih.gov/pubmed/31575379
http://dx.doi.org/10.1186/s12933-019-0932-z
_version_ 1783456036497129472
author Kim, Yun Gi
Han, Kyung-Do
Choi, Jong-Il
Boo, Ki Yung
Kim, Do Young
Oh, Suk-Kyu
Lee, Kwang-No
Shim, Jaemin
Kim, Jin Seok
Kim, Young-Hoon
author_facet Kim, Yun Gi
Han, Kyung-Do
Choi, Jong-Il
Boo, Ki Yung
Kim, Do Young
Oh, Suk-Kyu
Lee, Kwang-No
Shim, Jaemin
Kim, Jin Seok
Kim, Young-Hoon
author_sort Kim, Yun Gi
collection PubMed
description BACKGROUND: Being obese or underweight, and having diabetes are important risk factors for new-onset atrial fibrillation (AF). However, it is unclear whether there is any interaction between body weight and diabetes in regard to development of new-onset AF. We aimed to evaluate the role of body weight status and various stage of diabetes on new-onset AF. METHODS: This was a nationwide population based study using National Health Insurance Service (NHIS) data. A total of 9,797,418 patients who underwent national health check-ups were analyzed. Patients were classified as underweight [body mass index (BMI) < 18.5], normal reference group (18.5 ≤ BMI < 23.0), upper normal (23.0 ≤ BMI < 25.0), overweight (25.0 ≤ BMI < 30.0), or obese (BMI ≥ 30.0) based on BMI. Diabetes were categorized as non-diabetic, impaired fasting glucose (IFG), new-onset diabetes, diabetes < 5 years, and diabetes ≥ 5 years. Primary outcome end point was new-onset AF. New-onset AF was defined as one inpatient or two outpatient records of International Classification of Disease, Tenth Revision (ICD-10) codes in patients without prior AF diagnosis. RESULTS: During 80,130,161 patient*years follow-up, a total of 196,136 new-onset AF occurred. Obese [hazard ration (HR) = 1.327], overweight (HR = 1.123), upper normal (HR = 1.040), and underweight (HR = 1.055) patients showed significantly increased risk of new-onset AF compared to the normal reference group. Gradual escalation in the risk of new-onset AF was observed along with advancing diabetic stage. Body weight status and diabetes were independently associated with new-onset AF and at the same time, had synergistic effects on the risk of new-onset AF with obese diabetic patients having the highest risk (HR = 1.823). CONCLUSIONS: Patients with obesity, overweight, underweight, and diabetes had significantly increased risk of new-onset AF. Body weight status and diabetes had synergistic effects on the risk of new-onset AF. The risk of new-onset AF increased gradually with advancing diabetic stage. This study suggests that maintaining optimal body weight and glucose homeostasis might prevent new-onset AF.
format Online
Article
Text
id pubmed-6774211
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-67742112019-10-07 The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study Kim, Yun Gi Han, Kyung-Do Choi, Jong-Il Boo, Ki Yung Kim, Do Young Oh, Suk-Kyu Lee, Kwang-No Shim, Jaemin Kim, Jin Seok Kim, Young-Hoon Cardiovasc Diabetol Original Investigation BACKGROUND: Being obese or underweight, and having diabetes are important risk factors for new-onset atrial fibrillation (AF). However, it is unclear whether there is any interaction between body weight and diabetes in regard to development of new-onset AF. We aimed to evaluate the role of body weight status and various stage of diabetes on new-onset AF. METHODS: This was a nationwide population based study using National Health Insurance Service (NHIS) data. A total of 9,797,418 patients who underwent national health check-ups were analyzed. Patients were classified as underweight [body mass index (BMI) < 18.5], normal reference group (18.5 ≤ BMI < 23.0), upper normal (23.0 ≤ BMI < 25.0), overweight (25.0 ≤ BMI < 30.0), or obese (BMI ≥ 30.0) based on BMI. Diabetes were categorized as non-diabetic, impaired fasting glucose (IFG), new-onset diabetes, diabetes < 5 years, and diabetes ≥ 5 years. Primary outcome end point was new-onset AF. New-onset AF was defined as one inpatient or two outpatient records of International Classification of Disease, Tenth Revision (ICD-10) codes in patients without prior AF diagnosis. RESULTS: During 80,130,161 patient*years follow-up, a total of 196,136 new-onset AF occurred. Obese [hazard ration (HR) = 1.327], overweight (HR = 1.123), upper normal (HR = 1.040), and underweight (HR = 1.055) patients showed significantly increased risk of new-onset AF compared to the normal reference group. Gradual escalation in the risk of new-onset AF was observed along with advancing diabetic stage. Body weight status and diabetes were independently associated with new-onset AF and at the same time, had synergistic effects on the risk of new-onset AF with obese diabetic patients having the highest risk (HR = 1.823). CONCLUSIONS: Patients with obesity, overweight, underweight, and diabetes had significantly increased risk of new-onset AF. Body weight status and diabetes had synergistic effects on the risk of new-onset AF. The risk of new-onset AF increased gradually with advancing diabetic stage. This study suggests that maintaining optimal body weight and glucose homeostasis might prevent new-onset AF. BioMed Central 2019-10-01 /pmc/articles/PMC6774211/ /pubmed/31575379 http://dx.doi.org/10.1186/s12933-019-0932-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Investigation
Kim, Yun Gi
Han, Kyung-Do
Choi, Jong-Il
Boo, Ki Yung
Kim, Do Young
Oh, Suk-Kyu
Lee, Kwang-No
Shim, Jaemin
Kim, Jin Seok
Kim, Young-Hoon
The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
title The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
title_full The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
title_fullStr The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
title_full_unstemmed The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
title_short The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
title_sort impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774211/
https://www.ncbi.nlm.nih.gov/pubmed/31575379
http://dx.doi.org/10.1186/s12933-019-0932-z
work_keys_str_mv AT kimyungi theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT hankyungdo theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT choijongil theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT bookiyung theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT kimdoyoung theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT ohsukkyu theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT leekwangno theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT shimjaemin theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT kimjinseok theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT kimyounghoon theimpactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT kimyungi impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT hankyungdo impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT choijongil impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT bookiyung impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT kimdoyoung impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT ohsukkyu impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT leekwangno impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT shimjaemin impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT kimjinseok impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy
AT kimyounghoon impactofbodyweightanddiabetesonnewonsetatrialfibrillationanationwidepopulationbasedstudy