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Computational screening of antimicrobial peptides for Acinetobacter baumannii
Acinetobacter baumannii, has been developing resistance to even the last line of drugs. Antimicrobial peptides (AMPs) to which bacteria do not develop resistance easily may be the last hope. A few independent experimental studies have designed and studied the activity of AMPs on A. baumannii, howeve...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774513/ https://www.ncbi.nlm.nih.gov/pubmed/31577808 http://dx.doi.org/10.1371/journal.pone.0219693 |
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author | Majumder, Ayan Biswal, Malay Ranjan Prakash, Meher K. |
author_facet | Majumder, Ayan Biswal, Malay Ranjan Prakash, Meher K. |
author_sort | Majumder, Ayan |
collection | PubMed |
description | Acinetobacter baumannii, has been developing resistance to even the last line of drugs. Antimicrobial peptides (AMPs) to which bacteria do not develop resistance easily may be the last hope. A few independent experimental studies have designed and studied the activity of AMPs on A. baumannii, however the number of such studies are still limited. With the goal of developing a rational approach to the screening of AMPs against A. baumannii, we carefully curated the drug activity data from 75 cationic AMPs, all measured with a similar protocol, and on the same ATCC 19606 strain. A quantitative model developed and validated with a part of the data. While the model may be used for predicting the activity of any designed AMPs, in this work, we perform an in silico screening for the entire database of naturally occurring AMPs, to provide a rational guidance in this urgently needed drug development. |
format | Online Article Text |
id | pubmed-6774513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67745132019-10-12 Computational screening of antimicrobial peptides for Acinetobacter baumannii Majumder, Ayan Biswal, Malay Ranjan Prakash, Meher K. PLoS One Research Article Acinetobacter baumannii, has been developing resistance to even the last line of drugs. Antimicrobial peptides (AMPs) to which bacteria do not develop resistance easily may be the last hope. A few independent experimental studies have designed and studied the activity of AMPs on A. baumannii, however the number of such studies are still limited. With the goal of developing a rational approach to the screening of AMPs against A. baumannii, we carefully curated the drug activity data from 75 cationic AMPs, all measured with a similar protocol, and on the same ATCC 19606 strain. A quantitative model developed and validated with a part of the data. While the model may be used for predicting the activity of any designed AMPs, in this work, we perform an in silico screening for the entire database of naturally occurring AMPs, to provide a rational guidance in this urgently needed drug development. Public Library of Science 2019-10-02 /pmc/articles/PMC6774513/ /pubmed/31577808 http://dx.doi.org/10.1371/journal.pone.0219693 Text en © 2019 Majumder et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Majumder, Ayan Biswal, Malay Ranjan Prakash, Meher K. Computational screening of antimicrobial peptides for Acinetobacter baumannii |
title | Computational screening of antimicrobial peptides for Acinetobacter baumannii |
title_full | Computational screening of antimicrobial peptides for Acinetobacter baumannii |
title_fullStr | Computational screening of antimicrobial peptides for Acinetobacter baumannii |
title_full_unstemmed | Computational screening of antimicrobial peptides for Acinetobacter baumannii |
title_short | Computational screening of antimicrobial peptides for Acinetobacter baumannii |
title_sort | computational screening of antimicrobial peptides for acinetobacter baumannii |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774513/ https://www.ncbi.nlm.nih.gov/pubmed/31577808 http://dx.doi.org/10.1371/journal.pone.0219693 |
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