HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly

HIV-1 Gag protein assembles at the plasma membrane of infected cells for viral particle formation. Gag targets lipids, mainly PI(4,5)P2, at the inner leaflet of this membrane. Here, we address the question whether Gag is able to trap specifically PI(4,5)P2 or other lipids during HIV-1 assembly in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Favard, C., Chojnacki, J., Merida, P., Yandrapalli, N., Mak, J., Eggeling, C., Muriaux, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774721/
https://www.ncbi.nlm.nih.gov/pubmed/31616784
http://dx.doi.org/10.1126/sciadv.aaw8651

Ejemplares similares

Ejemplares similares