4D functional ultrasound imaging of whole-brain activity in rodents

We developed a technology that extends the capabilities of functional ultrasound to whole-brain 4D neuroimaging. We implemented multiplane wave transmissions on matrix arrays at thousands of frames per second to provide volumetric recordings of cerebral blood volume changes at high spatiotemporal re...

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Detalles Bibliográficos
Autores principales: Rabut, Claire, Correia, Mafalda, Finel, Victor, Pezet, Sophie, Pernot, Mathieu, Deffieux, Thomas, Tanter, Mickael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774790/
https://www.ncbi.nlm.nih.gov/pubmed/31548704
http://dx.doi.org/10.1038/s41592-019-0572-y
Descripción
Sumario:We developed a technology that extends the capabilities of functional ultrasound to whole-brain 4D neuroimaging. We implemented multiplane wave transmissions on matrix arrays at thousands of frames per second to provide volumetric recordings of cerebral blood volume changes at high spatiotemporal resolution. This approach is illustrated by several proofs-of-concept: real time multiple sensory stimuli, 4D functional connectivity and instantaneous tracking of epileptiform events within the whole brains of rodents.

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