A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis

Polyketide synthases assemble diverse natural products with numerous important applications. The thioester intermediates in polyketide assembly are covalently tethered to acyl carrier protein domains of the synthase. Several mechanisms for polyketide chain release are known, contributing to natural...

Descripción completa

Detalles Bibliográficos
Autores principales: Masschelein, Joleen, Sydor, Paulina K., Hobson, Christian, Howe, Rhiannon, Jones, Cerith, Roberts, Douglas M., Ling Yap, Zhong, Parkhill, Julian, Mahenthiralingam, Eshwar, Challis, Gregory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774797/
https://www.ncbi.nlm.nih.gov/pubmed/31548673
http://dx.doi.org/10.1038/s41557-019-0309-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774797/
https://www.ncbi.nlm.nih.gov/pubmed/31548673
http://dx.doi.org/10.1038/s41557-019-0309-7

Ejemplares similares