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A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis
Polyketide synthases assemble diverse natural products with numerous important applications. The thioester intermediates in polyketide assembly are covalently tethered to acyl carrier protein domains of the synthase. Several mechanisms for polyketide chain release are known, contributing to natural...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774797/ https://www.ncbi.nlm.nih.gov/pubmed/31548673 http://dx.doi.org/10.1038/s41557-019-0309-7 |