Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is characterized by continuous pain that is often accompanied by sensory, motor, vasomotor, sudomotor, and trophic disturbances. If left untreated, it can have a significant impact on the quality of life of patients. The diagnosis of CRPS is currently based on a...

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Autores principales: Bharwani, Krishna D., Dik, Willem A., Dirckx, Maaike, Huygen, Frank J. P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775035/
https://www.ncbi.nlm.nih.gov/pubmed/31363934
http://dx.doi.org/10.1007/s40291-019-00417-x
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author Bharwani, Krishna D.
Dik, Willem A.
Dirckx, Maaike
Huygen, Frank J. P. M.
author_facet Bharwani, Krishna D.
Dik, Willem A.
Dirckx, Maaike
Huygen, Frank J. P. M.
author_sort Bharwani, Krishna D.
collection PubMed
description Complex regional pain syndrome (CRPS) is characterized by continuous pain that is often accompanied by sensory, motor, vasomotor, sudomotor, and trophic disturbances. If left untreated, it can have a significant impact on the quality of life of patients. The diagnosis of CRPS is currently based on a set of relatively subjective clinical criteria: the New International Association for the Study of Pain clinical diagnostic criteria for CRPS. There are still no objective laboratory tests to diagnose CRPS and there is a great need for simple, objective, and easily measurable biomarkers in the diagnosis and management of this disease. In this review, we discuss the role of inflammation in the multi-mechanism pathophysiology of CRPS and highlight the application of potential biomarkers of inflammation in the diagnosis and management of this disease.
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spelling pubmed-67750352019-10-17 Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome Bharwani, Krishna D. Dik, Willem A. Dirckx, Maaike Huygen, Frank J. P. M. Mol Diagn Ther Review Article Complex regional pain syndrome (CRPS) is characterized by continuous pain that is often accompanied by sensory, motor, vasomotor, sudomotor, and trophic disturbances. If left untreated, it can have a significant impact on the quality of life of patients. The diagnosis of CRPS is currently based on a set of relatively subjective clinical criteria: the New International Association for the Study of Pain clinical diagnostic criteria for CRPS. There are still no objective laboratory tests to diagnose CRPS and there is a great need for simple, objective, and easily measurable biomarkers in the diagnosis and management of this disease. In this review, we discuss the role of inflammation in the multi-mechanism pathophysiology of CRPS and highlight the application of potential biomarkers of inflammation in the diagnosis and management of this disease. Springer International Publishing 2019-07-30 2019 /pmc/articles/PMC6775035/ /pubmed/31363934 http://dx.doi.org/10.1007/s40291-019-00417-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Bharwani, Krishna D.
Dik, Willem A.
Dirckx, Maaike
Huygen, Frank J. P. M.
Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome
title Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome
title_full Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome
title_fullStr Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome
title_full_unstemmed Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome
title_short Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome
title_sort highlighting the role of biomarkers of inflammation in the diagnosis and management of complex regional pain syndrome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775035/
https://www.ncbi.nlm.nih.gov/pubmed/31363934
http://dx.doi.org/10.1007/s40291-019-00417-x
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