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Gram-negative synergy and mechanism of action of alkynyl bisbenzimidazoles

Bisbenzimidazoles with terminal alkynyl linkers, selective inhibitors of bacterial topoisomerase I, have been evaluated using bacterial cytological profiling (BCP) to ascertain their mechanism of action and screened for synergism to improve Gram-negative bacterial coverage. Principal component analy...

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Detalles Bibliográficos
Autores principales:	Chamberlin, Jordan, Story, Sandra, Ranjan, Nihar, Chesser, Geoffrey, Arya, Dev P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775084/ https://www.ncbi.nlm.nih.gov/pubmed/31578425 http://dx.doi.org/10.1038/s41598-019-48898-4

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