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A robust bacterial assay for high-throughput screening of human 4-hydroxyphenylpyruvate dioxygenase inhibitors

Hereditary tyrosinemia type 1 (HT1) and alkaptonuria (AKU) are inherited metabolic disorders caused by defective enzymes involved in tyrosine catabolism. Nitisinone, an ex-herbicide and member of the β-triketone family, is therapeutically applied to prevent accumulation of toxic metabolites in patie...

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Detalles Bibliográficos
Autores principales:	Neuckermans, Jessie, Mertens, Alan, De Win, Dinja, Schwaneberg, Ulrich, De Kock, Joery
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775094/ https://www.ncbi.nlm.nih.gov/pubmed/31578365 http://dx.doi.org/10.1038/s41598-019-50533-1

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