Genome-wide association study and whole-genome sequencing identify a deletion in LRIT3 associated with canine congenital stationary night blindness

Congenital stationary night blindness (CSNB), in the complete form, is caused by dysfunctions in ON-bipolar cells (ON-BCs) which are secondary neurons of the retina. We describe the first disease causative variant associated with CSNB in the dog. A genome-wide association study using 12 cases and 11...

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Detalles Bibliográficos
Autores principales: Das, Rueben G., Becker, Doreen, Jagannathan, Vidhya, Goldstein, Orly, Santana, Evelyn, Carlin, Kendall, Sudharsan, Raghavi, Leeb, Tosso, Nishizawa, Yuji, Kondo, Mineo, Aguirre, Gustavo D., Miyadera, Keiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775105/
https://www.ncbi.nlm.nih.gov/pubmed/31578364
http://dx.doi.org/10.1038/s41598-019-50573-7

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