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MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease
One of the major challenges in chronic Chagas disease is to understand the mechanisms that predict the clinical evolution from asymptomatic to severe cardiac clinical forms. Our cohort consisted of twenty-eight Chagas disease patients followed for twenty years. Plasma levels of MMP-2 and MMP-9 gelat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775161/ https://www.ncbi.nlm.nih.gov/pubmed/31578449 http://dx.doi.org/10.1038/s41598-019-50791-z |
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author | Medeiros, Nayara I. Gomes, Juliana A. S. Fiuza, Jacqueline A. Sousa, Giovane R. Almeida, Eliane F. Novaes, Renata O. Rocha, Virgínia L. S. Chaves, Ana T. Dutra, Walderez O. Rocha, Manoel O. C. Correa-Oliveira, Rodrigo |
author_facet | Medeiros, Nayara I. Gomes, Juliana A. S. Fiuza, Jacqueline A. Sousa, Giovane R. Almeida, Eliane F. Novaes, Renata O. Rocha, Virgínia L. S. Chaves, Ana T. Dutra, Walderez O. Rocha, Manoel O. C. Correa-Oliveira, Rodrigo |
author_sort | Medeiros, Nayara I. |
collection | PubMed |
description | One of the major challenges in chronic Chagas disease is to understand the mechanisms that predict the clinical evolution from asymptomatic to severe cardiac clinical forms. Our cohort consisted of twenty-eight Chagas disease patients followed for twenty years. Plasma levels of MMP-2 and MMP-9 gelatinases and TIMPs were evaluated by multiplexed immunoassay at two points in time with an average interval of six years. MMP-2 plasma levels, but not MMP-9, increased in cardiac patients over time. TIMP-1 levels diminished in cardiac patients, while TIMP-3 dropped in asymptomatic patients in the course of the evaluated interval. An inversion of time lines was observed relative to the clinical asymptomatic and cardiac forms for MMP-2. Receiver Operating Characteristic (ROC) curve analysis identified MMP-2 as a biomarker to distinguish asymptomatic from cardiac clinical forms, while MMP-9 is a biomarker that segregates infected from non-infected patients. We have pointed out that MMP-2 and MMP-9 together can predict clinical evolution in Chagas disease. MMP-2 was suggested as a biomarker for fibrosis replacement in early remodeling and a sensitive predictor for initial changes in asymptomatic patients that may evolve into the cardiac clinical form. MMP-9 seems to be a biomarker for late fibrosis and severe cardiac remodeling in cardiac patients. |
format | Online Article Text |
id | pubmed-6775161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67751612019-10-09 MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease Medeiros, Nayara I. Gomes, Juliana A. S. Fiuza, Jacqueline A. Sousa, Giovane R. Almeida, Eliane F. Novaes, Renata O. Rocha, Virgínia L. S. Chaves, Ana T. Dutra, Walderez O. Rocha, Manoel O. C. Correa-Oliveira, Rodrigo Sci Rep Article One of the major challenges in chronic Chagas disease is to understand the mechanisms that predict the clinical evolution from asymptomatic to severe cardiac clinical forms. Our cohort consisted of twenty-eight Chagas disease patients followed for twenty years. Plasma levels of MMP-2 and MMP-9 gelatinases and TIMPs were evaluated by multiplexed immunoassay at two points in time with an average interval of six years. MMP-2 plasma levels, but not MMP-9, increased in cardiac patients over time. TIMP-1 levels diminished in cardiac patients, while TIMP-3 dropped in asymptomatic patients in the course of the evaluated interval. An inversion of time lines was observed relative to the clinical asymptomatic and cardiac forms for MMP-2. Receiver Operating Characteristic (ROC) curve analysis identified MMP-2 as a biomarker to distinguish asymptomatic from cardiac clinical forms, while MMP-9 is a biomarker that segregates infected from non-infected patients. We have pointed out that MMP-2 and MMP-9 together can predict clinical evolution in Chagas disease. MMP-2 was suggested as a biomarker for fibrosis replacement in early remodeling and a sensitive predictor for initial changes in asymptomatic patients that may evolve into the cardiac clinical form. MMP-9 seems to be a biomarker for late fibrosis and severe cardiac remodeling in cardiac patients. Nature Publishing Group UK 2019-10-02 /pmc/articles/PMC6775161/ /pubmed/31578449 http://dx.doi.org/10.1038/s41598-019-50791-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Medeiros, Nayara I. Gomes, Juliana A. S. Fiuza, Jacqueline A. Sousa, Giovane R. Almeida, Eliane F. Novaes, Renata O. Rocha, Virgínia L. S. Chaves, Ana T. Dutra, Walderez O. Rocha, Manoel O. C. Correa-Oliveira, Rodrigo MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease |
title | MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease |
title_full | MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease |
title_fullStr | MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease |
title_full_unstemmed | MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease |
title_short | MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease |
title_sort | mmp-2 and mmp-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic chagas disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775161/ https://www.ncbi.nlm.nih.gov/pubmed/31578449 http://dx.doi.org/10.1038/s41598-019-50791-z |
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