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MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease

One of the major challenges in chronic Chagas disease is to understand the mechanisms that predict the clinical evolution from asymptomatic to severe cardiac clinical forms. Our cohort consisted of twenty-eight Chagas disease patients followed for twenty years. Plasma levels of MMP-2 and MMP-9 gelat...

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Autores principales: Medeiros, Nayara I., Gomes, Juliana A. S., Fiuza, Jacqueline A., Sousa, Giovane R., Almeida, Eliane F., Novaes, Renata O., Rocha, Virgínia L. S., Chaves, Ana T., Dutra, Walderez O., Rocha, Manoel O. C., Correa-Oliveira, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775161/
https://www.ncbi.nlm.nih.gov/pubmed/31578449
http://dx.doi.org/10.1038/s41598-019-50791-z
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author Medeiros, Nayara I.
Gomes, Juliana A. S.
Fiuza, Jacqueline A.
Sousa, Giovane R.
Almeida, Eliane F.
Novaes, Renata O.
Rocha, Virgínia L. S.
Chaves, Ana T.
Dutra, Walderez O.
Rocha, Manoel O. C.
Correa-Oliveira, Rodrigo
author_facet Medeiros, Nayara I.
Gomes, Juliana A. S.
Fiuza, Jacqueline A.
Sousa, Giovane R.
Almeida, Eliane F.
Novaes, Renata O.
Rocha, Virgínia L. S.
Chaves, Ana T.
Dutra, Walderez O.
Rocha, Manoel O. C.
Correa-Oliveira, Rodrigo
author_sort Medeiros, Nayara I.
collection PubMed
description One of the major challenges in chronic Chagas disease is to understand the mechanisms that predict the clinical evolution from asymptomatic to severe cardiac clinical forms. Our cohort consisted of twenty-eight Chagas disease patients followed for twenty years. Plasma levels of MMP-2 and MMP-9 gelatinases and TIMPs were evaluated by multiplexed immunoassay at two points in time with an average interval of six years. MMP-2 plasma levels, but not MMP-9, increased in cardiac patients over time. TIMP-1 levels diminished in cardiac patients, while TIMP-3 dropped in asymptomatic patients in the course of the evaluated interval. An inversion of time lines was observed relative to the clinical asymptomatic and cardiac forms for MMP-2. Receiver Operating Characteristic (ROC) curve analysis identified MMP-2 as a biomarker to distinguish asymptomatic from cardiac clinical forms, while MMP-9 is a biomarker that segregates infected from non-infected patients. We have pointed out that MMP-2 and MMP-9 together can predict clinical evolution in Chagas disease. MMP-2 was suggested as a biomarker for fibrosis replacement in early remodeling and a sensitive predictor for initial changes in asymptomatic patients that may evolve into the cardiac clinical form. MMP-9 seems to be a biomarker for late fibrosis and severe cardiac remodeling in cardiac patients.
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spelling pubmed-67751612019-10-09 MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease Medeiros, Nayara I. Gomes, Juliana A. S. Fiuza, Jacqueline A. Sousa, Giovane R. Almeida, Eliane F. Novaes, Renata O. Rocha, Virgínia L. S. Chaves, Ana T. Dutra, Walderez O. Rocha, Manoel O. C. Correa-Oliveira, Rodrigo Sci Rep Article One of the major challenges in chronic Chagas disease is to understand the mechanisms that predict the clinical evolution from asymptomatic to severe cardiac clinical forms. Our cohort consisted of twenty-eight Chagas disease patients followed for twenty years. Plasma levels of MMP-2 and MMP-9 gelatinases and TIMPs were evaluated by multiplexed immunoassay at two points in time with an average interval of six years. MMP-2 plasma levels, but not MMP-9, increased in cardiac patients over time. TIMP-1 levels diminished in cardiac patients, while TIMP-3 dropped in asymptomatic patients in the course of the evaluated interval. An inversion of time lines was observed relative to the clinical asymptomatic and cardiac forms for MMP-2. Receiver Operating Characteristic (ROC) curve analysis identified MMP-2 as a biomarker to distinguish asymptomatic from cardiac clinical forms, while MMP-9 is a biomarker that segregates infected from non-infected patients. We have pointed out that MMP-2 and MMP-9 together can predict clinical evolution in Chagas disease. MMP-2 was suggested as a biomarker for fibrosis replacement in early remodeling and a sensitive predictor for initial changes in asymptomatic patients that may evolve into the cardiac clinical form. MMP-9 seems to be a biomarker for late fibrosis and severe cardiac remodeling in cardiac patients. Nature Publishing Group UK 2019-10-02 /pmc/articles/PMC6775161/ /pubmed/31578449 http://dx.doi.org/10.1038/s41598-019-50791-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Medeiros, Nayara I.
Gomes, Juliana A. S.
Fiuza, Jacqueline A.
Sousa, Giovane R.
Almeida, Eliane F.
Novaes, Renata O.
Rocha, Virgínia L. S.
Chaves, Ana T.
Dutra, Walderez O.
Rocha, Manoel O. C.
Correa-Oliveira, Rodrigo
MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease
title MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease
title_full MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease
title_fullStr MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease
title_full_unstemmed MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease
title_short MMP-2 and MMP-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic Chagas disease
title_sort mmp-2 and mmp-9 plasma levels are potential biomarkers for indeterminate and cardiac clinical forms progression in chronic chagas disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775161/
https://www.ncbi.nlm.nih.gov/pubmed/31578449
http://dx.doi.org/10.1038/s41598-019-50791-z
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