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Widespread brain reorganization perturbs visuomotor coordination in early glaucoma

Glaucoma is the world’s leading cause of irreversible blindness, and falls are a major public health concern in glaucoma patients. Although recent evidence suggests the involvements of the brain toward advanced glaucoma stages, the early brain changes and their clinical and behavioral consequences r...

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Autores principales: Trivedi, Vivek, Bang, Ji Won, Parra, Carlos, Colbert, Max K., O’Connell, Caitlin, Arshad, Ahmel, Faiq, Muneeb A., Conner, Ian P., Redfern, Mark S., Wollstein, Gadi, Schuman, Joel S., Cham, Rakie, Chan, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775162/
https://www.ncbi.nlm.nih.gov/pubmed/31578409
http://dx.doi.org/10.1038/s41598-019-50793-x
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author Trivedi, Vivek
Bang, Ji Won
Parra, Carlos
Colbert, Max K.
O’Connell, Caitlin
Arshad, Ahmel
Faiq, Muneeb A.
Conner, Ian P.
Redfern, Mark S.
Wollstein, Gadi
Schuman, Joel S.
Cham, Rakie
Chan, Kevin C.
author_facet Trivedi, Vivek
Bang, Ji Won
Parra, Carlos
Colbert, Max K.
O’Connell, Caitlin
Arshad, Ahmel
Faiq, Muneeb A.
Conner, Ian P.
Redfern, Mark S.
Wollstein, Gadi
Schuman, Joel S.
Cham, Rakie
Chan, Kevin C.
author_sort Trivedi, Vivek
collection PubMed
description Glaucoma is the world’s leading cause of irreversible blindness, and falls are a major public health concern in glaucoma patients. Although recent evidence suggests the involvements of the brain toward advanced glaucoma stages, the early brain changes and their clinical and behavioral consequences remain poorly described. This study aims to determine how glaucoma may impair the brain structurally and functionally within and beyond the visual pathway in the early stages, and whether these changes can explain visuomotor impairments in glaucoma. Using multi-parametric magnetic resonance imaging, glaucoma patients presented compromised white matter integrity along the central visual pathway and around the supramarginal gyrus, as well as reduced functional connectivity between the supramarginal gyrus and the visual occipital and superior sensorimotor areas when compared to healthy controls. Furthermore, decreased functional connectivity between the supramarginal gyrus and the visual brain network may negatively impact postural control measured with dynamic posturography in glaucoma patients. Taken together, this study demonstrates that widespread structural and functional brain reorganization is taking place in areas associated with visuomotor coordination in early glaucoma. These results implicate an important central mechanism by which glaucoma patients may be susceptible to visual impairments and increased risk of falls.
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spelling pubmed-67751622019-10-09 Widespread brain reorganization perturbs visuomotor coordination in early glaucoma Trivedi, Vivek Bang, Ji Won Parra, Carlos Colbert, Max K. O’Connell, Caitlin Arshad, Ahmel Faiq, Muneeb A. Conner, Ian P. Redfern, Mark S. Wollstein, Gadi Schuman, Joel S. Cham, Rakie Chan, Kevin C. Sci Rep Article Glaucoma is the world’s leading cause of irreversible blindness, and falls are a major public health concern in glaucoma patients. Although recent evidence suggests the involvements of the brain toward advanced glaucoma stages, the early brain changes and their clinical and behavioral consequences remain poorly described. This study aims to determine how glaucoma may impair the brain structurally and functionally within and beyond the visual pathway in the early stages, and whether these changes can explain visuomotor impairments in glaucoma. Using multi-parametric magnetic resonance imaging, glaucoma patients presented compromised white matter integrity along the central visual pathway and around the supramarginal gyrus, as well as reduced functional connectivity between the supramarginal gyrus and the visual occipital and superior sensorimotor areas when compared to healthy controls. Furthermore, decreased functional connectivity between the supramarginal gyrus and the visual brain network may negatively impact postural control measured with dynamic posturography in glaucoma patients. Taken together, this study demonstrates that widespread structural and functional brain reorganization is taking place in areas associated with visuomotor coordination in early glaucoma. These results implicate an important central mechanism by which glaucoma patients may be susceptible to visual impairments and increased risk of falls. Nature Publishing Group UK 2019-10-02 /pmc/articles/PMC6775162/ /pubmed/31578409 http://dx.doi.org/10.1038/s41598-019-50793-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Trivedi, Vivek
Bang, Ji Won
Parra, Carlos
Colbert, Max K.
O’Connell, Caitlin
Arshad, Ahmel
Faiq, Muneeb A.
Conner, Ian P.
Redfern, Mark S.
Wollstein, Gadi
Schuman, Joel S.
Cham, Rakie
Chan, Kevin C.
Widespread brain reorganization perturbs visuomotor coordination in early glaucoma
title Widespread brain reorganization perturbs visuomotor coordination in early glaucoma
title_full Widespread brain reorganization perturbs visuomotor coordination in early glaucoma
title_fullStr Widespread brain reorganization perturbs visuomotor coordination in early glaucoma
title_full_unstemmed Widespread brain reorganization perturbs visuomotor coordination in early glaucoma
title_short Widespread brain reorganization perturbs visuomotor coordination in early glaucoma
title_sort widespread brain reorganization perturbs visuomotor coordination in early glaucoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775162/
https://www.ncbi.nlm.nih.gov/pubmed/31578409
http://dx.doi.org/10.1038/s41598-019-50793-x
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