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Fermentative Production of N-Alkylated Glycine Derivatives by Recombinant Corynebacterium glutamicum Using a Mutant of Imine Reductase DpkA From Pseudomonas putida
Sarcosine, an N-methylated amino acid, shows potential as antipsychotic, and serves as building block for peptide-based drugs, and acts as detergent when acetylated. N-methylated amino acids are mainly produced chemically or by biocatalysis, with either low yields or high costs for co-factor regener...
Autores principales: | Mindt, Melanie, Hannibal, Silvin, Heuser, Maria, Risse, Joe Max, Sasikumar, Keerthi, Nampoothiri, K. Madhavan, Wendisch, Volker F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775277/ https://www.ncbi.nlm.nih.gov/pubmed/31616665 http://dx.doi.org/10.3389/fbioe.2019.00232 |
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