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Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair
Recently there has been an increasing interest in bioactive factors with robust osteogenic ability and angiogenesis function to repair bone defects. However, previously tested factors have not achieved satisfactory results due to low loading doses and a short protein half-life. Finding a validated s...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775301/ https://www.ncbi.nlm.nih.gov/pubmed/31592233 http://dx.doi.org/10.7150/ijbs.35670 |
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author | Wang, Wei Liu, Yang Yang, Chao Qi, Xin Li, Shuangwu Liu, Changsheng Li, Xiaolin |
author_facet | Wang, Wei Liu, Yang Yang, Chao Qi, Xin Li, Shuangwu Liu, Changsheng Li, Xiaolin |
author_sort | Wang, Wei |
collection | PubMed |
description | Recently there has been an increasing interest in bioactive factors with robust osteogenic ability and angiogenesis function to repair bone defects. However, previously tested factors have not achieved satisfactory results due to low loading doses and a short protein half-life. Finding a validated stable substitute for these growth factors and apply it to the construction of porous scaffolds with the dual function of osteogenesis and angiogenesis is therefore vital for bone tissue regeneration engineering. Graphene oxide (GO) has attracted increasing attention due to its good biocompatibility, osteogenic, and angiogenic functions. This study aims to design a scaffold composed of mesoporous bioactive glasses (MBG) and GO to investigate whether the composite porous scaffold promotes local angiogenesis and bone healing. Our in vitro studies demonstrate that the MBG-GO scaffolds have better cytocompatibility and higher osteogenesis differentiation ability with rat bone marrow mesenchymal stem cells (rBMSCs) than the purely MBG scaffold. Moreover, MBG-GO scaffolds promote vascular ingrowth and, importantly, enhance bone repair at the defect site in a rat cranial defect model. The new bone was fully integrated not only with the periphery but also with the center of the scaffold. From these results, it is believed that the MBG-GO scaffolds possess excellent osteogenic-angiogenic properties which will make them appealing candidates for repairing bone defects. The novelty of this research is to provide a new material to treat bone defects in the clinic. |
format | Online Article Text |
id | pubmed-6775301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-67753012019-10-07 Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair Wang, Wei Liu, Yang Yang, Chao Qi, Xin Li, Shuangwu Liu, Changsheng Li, Xiaolin Int J Biol Sci Research Paper Recently there has been an increasing interest in bioactive factors with robust osteogenic ability and angiogenesis function to repair bone defects. However, previously tested factors have not achieved satisfactory results due to low loading doses and a short protein half-life. Finding a validated stable substitute for these growth factors and apply it to the construction of porous scaffolds with the dual function of osteogenesis and angiogenesis is therefore vital for bone tissue regeneration engineering. Graphene oxide (GO) has attracted increasing attention due to its good biocompatibility, osteogenic, and angiogenic functions. This study aims to design a scaffold composed of mesoporous bioactive glasses (MBG) and GO to investigate whether the composite porous scaffold promotes local angiogenesis and bone healing. Our in vitro studies demonstrate that the MBG-GO scaffolds have better cytocompatibility and higher osteogenesis differentiation ability with rat bone marrow mesenchymal stem cells (rBMSCs) than the purely MBG scaffold. Moreover, MBG-GO scaffolds promote vascular ingrowth and, importantly, enhance bone repair at the defect site in a rat cranial defect model. The new bone was fully integrated not only with the periphery but also with the center of the scaffold. From these results, it is believed that the MBG-GO scaffolds possess excellent osteogenic-angiogenic properties which will make them appealing candidates for repairing bone defects. The novelty of this research is to provide a new material to treat bone defects in the clinic. Ivyspring International Publisher 2019-08-08 /pmc/articles/PMC6775301/ /pubmed/31592233 http://dx.doi.org/10.7150/ijbs.35670 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Wang, Wei Liu, Yang Yang, Chao Qi, Xin Li, Shuangwu Liu, Changsheng Li, Xiaolin Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair |
title | Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair |
title_full | Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair |
title_fullStr | Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair |
title_full_unstemmed | Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair |
title_short | Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair |
title_sort | mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775301/ https://www.ncbi.nlm.nih.gov/pubmed/31592233 http://dx.doi.org/10.7150/ijbs.35670 |
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