The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer

SEC23, the core component of the coat protein complex II (COPII), functions to transport newly synthesized proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus in cells for secretion. SEC23 protein has two isoforms (SEC23A and SEC23B) and their aberrant expression and mutat...

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Detalles Bibliográficos
Autores principales: Jing, Jingchen, Wang, Bo, Liu, Peijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775307/
https://www.ncbi.nlm.nih.gov/pubmed/31595159
http://dx.doi.org/10.7150/ijbs.37008
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author Jing, Jingchen
Wang, Bo
Liu, Peijun
author_facet Jing, Jingchen
Wang, Bo
Liu, Peijun
author_sort Jing, Jingchen
collection PubMed
description SEC23, the core component of the coat protein complex II (COPII), functions to transport newly synthesized proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus in cells for secretion. SEC23 protein has two isoforms (SEC23A and SEC23B) and their aberrant expression and mutations were reported to cause human diseases and oncogenesis, whereas SEC23A and SEC23B may have the opposite activity in human cancer, for a reason that remains unclear. This review summarizes recent research in SEC23, COPII-vesicle transportation, autophagy, and cancer.
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spelling pubmed-67753072019-10-08 The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer Jing, Jingchen Wang, Bo Liu, Peijun Int J Biol Sci Review SEC23, the core component of the coat protein complex II (COPII), functions to transport newly synthesized proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus in cells for secretion. SEC23 protein has two isoforms (SEC23A and SEC23B) and their aberrant expression and mutations were reported to cause human diseases and oncogenesis, whereas SEC23A and SEC23B may have the opposite activity in human cancer, for a reason that remains unclear. This review summarizes recent research in SEC23, COPII-vesicle transportation, autophagy, and cancer. Ivyspring International Publisher 2019-09-07 /pmc/articles/PMC6775307/ /pubmed/31595159 http://dx.doi.org/10.7150/ijbs.37008 Text en © The author (s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Jing, Jingchen
Wang, Bo
Liu, Peijun
The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer
title The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer
title_full The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer
title_fullStr The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer
title_full_unstemmed The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer
title_short The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer
title_sort functional role of sec23 in vesicle transportation, autophagy and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775307/
https://www.ncbi.nlm.nih.gov/pubmed/31595159
http://dx.doi.org/10.7150/ijbs.37008
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