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Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery

Breast cancer is the most common cancer among women worldwide, and it is a main cause of death in women. As with breast cancer, metabolic components are important risk factors for the development of nonalcoholic fatty liver disease (NAFLD). In this retrospective cohort study, we aimed to determine t...

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Autores principales: Lee, Young-Sun, Lee, Ha Seok, Chang, Sung Won, Lee, Chan Uk, Kim, Jung Sun, Jung, Young Kul, Kim, Ji Hoon, Seo, Yeon Seok, Yim, Hyung Joon, Lee, Chang Hee, Woo, Sang Uk, Seo, Jae Hong, Yeon, Jong Eun, Um, Soon Ho, Byun, Kwan Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775430/
https://www.ncbi.nlm.nih.gov/pubmed/31574842
http://dx.doi.org/10.1097/MD.0000000000017277
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author Lee, Young-Sun
Lee, Ha Seok
Chang, Sung Won
Lee, Chan Uk
Kim, Jung Sun
Jung, Young Kul
Kim, Ji Hoon
Seo, Yeon Seok
Yim, Hyung Joon
Lee, Chang Hee
Woo, Sang Uk
Seo, Jae Hong
Yeon, Jong Eun
Um, Soon Ho
Byun, Kwan Soo
author_facet Lee, Young-Sun
Lee, Ha Seok
Chang, Sung Won
Lee, Chan Uk
Kim, Jung Sun
Jung, Young Kul
Kim, Ji Hoon
Seo, Yeon Seok
Yim, Hyung Joon
Lee, Chang Hee
Woo, Sang Uk
Seo, Jae Hong
Yeon, Jong Eun
Um, Soon Ho
Byun, Kwan Soo
author_sort Lee, Young-Sun
collection PubMed
description Breast cancer is the most common cancer among women worldwide, and it is a main cause of death in women. As with breast cancer, metabolic components are important risk factors for the development of nonalcoholic fatty liver disease (NAFLD). In this retrospective cohort study, we aimed to determine the prevalence of NAFLD in patients with breast cancer and the impact of NAFLD on the prognosis of breast cancer. Patients with breast cancer were enrolled in the study from January 2007 to June 2017. Hepatic steatosis was evaluated through non-enhanced computed tomography scan by measuring Hounsfield Units in the liver and spleen, respectively; 123 healthy controls who underwent non-enhanced computed tomography scan were also analyzed. The prevalence of NAFLD in patients with breast cancer was 15.8% (251/1587), which was significantly higher than in healthy controls (8.9%, 11/123) (P = .036). Overall survival did not significantly differ between the groups with and without NAFLD (P = .304). However, recurrence-free survival was significantly higher in patients without NAFLD than in those with NAFLD (P = .009). Among breast cancer patients receiving endocrine treatment, the NAFLD group showed a higher cumulative incidence of significant liver injury than the group without NAFLD (P < .001). The prevalence of NAFLD in patients with breast cancer is significantly higher than in healthy controls. Moreover, breast cancer patients with NAFLD showed poorer prognosis in terms of recurrence. Therefore, diagnostic evaluation for NALFD is important in managing patients with breast cancer.
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spelling pubmed-67754302019-10-07 Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery Lee, Young-Sun Lee, Ha Seok Chang, Sung Won Lee, Chan Uk Kim, Jung Sun Jung, Young Kul Kim, Ji Hoon Seo, Yeon Seok Yim, Hyung Joon Lee, Chang Hee Woo, Sang Uk Seo, Jae Hong Yeon, Jong Eun Um, Soon Ho Byun, Kwan Soo Medicine (Baltimore) 4500 Breast cancer is the most common cancer among women worldwide, and it is a main cause of death in women. As with breast cancer, metabolic components are important risk factors for the development of nonalcoholic fatty liver disease (NAFLD). In this retrospective cohort study, we aimed to determine the prevalence of NAFLD in patients with breast cancer and the impact of NAFLD on the prognosis of breast cancer. Patients with breast cancer were enrolled in the study from January 2007 to June 2017. Hepatic steatosis was evaluated through non-enhanced computed tomography scan by measuring Hounsfield Units in the liver and spleen, respectively; 123 healthy controls who underwent non-enhanced computed tomography scan were also analyzed. The prevalence of NAFLD in patients with breast cancer was 15.8% (251/1587), which was significantly higher than in healthy controls (8.9%, 11/123) (P = .036). Overall survival did not significantly differ between the groups with and without NAFLD (P = .304). However, recurrence-free survival was significantly higher in patients without NAFLD than in those with NAFLD (P = .009). Among breast cancer patients receiving endocrine treatment, the NAFLD group showed a higher cumulative incidence of significant liver injury than the group without NAFLD (P < .001). The prevalence of NAFLD in patients with breast cancer is significantly higher than in healthy controls. Moreover, breast cancer patients with NAFLD showed poorer prognosis in terms of recurrence. Therefore, diagnostic evaluation for NALFD is important in managing patients with breast cancer. Wolters Kluwer Health 2019-09-27 /pmc/articles/PMC6775430/ /pubmed/31574842 http://dx.doi.org/10.1097/MD.0000000000017277 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4500
Lee, Young-Sun
Lee, Ha Seok
Chang, Sung Won
Lee, Chan Uk
Kim, Jung Sun
Jung, Young Kul
Kim, Ji Hoon
Seo, Yeon Seok
Yim, Hyung Joon
Lee, Chang Hee
Woo, Sang Uk
Seo, Jae Hong
Yeon, Jong Eun
Um, Soon Ho
Byun, Kwan Soo
Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery
title Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery
title_full Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery
title_fullStr Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery
title_full_unstemmed Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery
title_short Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery
title_sort underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775430/
https://www.ncbi.nlm.nih.gov/pubmed/31574842
http://dx.doi.org/10.1097/MD.0000000000017277
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