Influenza Virus Polymerase Mutation Stabilizes a Foreign Gene Inserted into the Virus Genome by Enhancing the Transcription/Replication Efficiency of the Modified Segment

We previously attempted to establish a reporter influenza virus by inserting the gene for the Venus fluorescent protein into the NS segment of influenza A/Puerto Rico/8/34 (PR8, H1N1) virus to yield WT-Venus-PR8. Although the inserted Venus gene was deleted during serial passages of WT-Venus-PR8, we...

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Detalles Bibliográficos
Autores principales: Furusawa, Yuri, Yamada, Shinya, da Silva Lopes, Tiago Jose, Dutta, Jayeeta, Khan, Zenab, Kriti, Divya, van Bakel, Harm, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775454/
https://www.ncbi.nlm.nih.gov/pubmed/31575766
http://dx.doi.org/10.1128/mBio.01794-19

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