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Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro
Human norovirus (HuNoV) is the main cause of gastroenteritis worldwide, yet no therapeutics are currently available. Here, we utilize a human norovirus replicon in human gastric tumor (HGT) cells to identify host factors involved in promoting or inhibiting HuNoV replication. We observed that an inte...
Autores principales: | Arthur, Sabastine E., Sorgeloos, Frédéric, Hosmillo, Myra, Goodfellow, Ian G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775457/ https://www.ncbi.nlm.nih.gov/pubmed/31575769 http://dx.doi.org/10.1128/mBio.02155-19 |
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