Update on current pancreatic treatments: from molecular pathways to treatment

Pancreatic cancer is still diagnosed at a late stage although we have novel diagnostic tools. Pancreatic cancer chemotherapy treatment resistance is observed and therefore novel treatments are in need. Anti-cancer stem cell therapy, combination of chemotherapy and/or radiotherapy with immunotherapy,...

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Detalles Bibliográficos
Autores principales: Sapalidis, Konstantinos, Kosmidis, Christoforos, Funtanidou, Varvara, Katsaounis, Athanasios, Barmpas, Amastasios, Koimtzis, Georgios, Mantalobas, Stylianos, Alexandrou, Vyron, Aidoni, Zoi, Koulouris, Charilaos, Pavlidis, Efstathios, Giannakidis, Dimitrios, Surlin, Valeriu, Pantea, Stelian, Strambu, Victor, Constantina, Rogoveanu Otilia, Amaniti, Aikaterini, Zarogoulidis, Paul, Mogoantă, Stelian, Kesisoglou, Isaak, Sardeli, Chrysanthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775621/
https://www.ncbi.nlm.nih.gov/pubmed/31602269
http://dx.doi.org/10.7150/jca.36300
Descripción
Sumario:Pancreatic cancer is still diagnosed at a late stage although we have novel diagnostic tools. Pancreatic cancer chemotherapy treatment resistance is observed and therefore novel treatments are in need. Anti-cancer stem cell therapy, combination of chemotherapy and/or radiotherapy with immunotherapy, proteins/enzymes and gene therapy are currently under evaluation. Targeted treatment with tyrosine kinase inhibitors is also administered and novel inhibitors are also under evaluation. In the current review we present recent data from our search within the year 2018.

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