Cargando…

Macrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis

Tumor-associated macrophages (TAM) have been shown to support tumor growth and progression by various mechanisms. However, the roles of TAM in gastric cancer (GC) peritoneal metastasis remain elusive. To explore the roles of macrophages in the process of GC peritoneal metastasis, we performed the pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Hongjiang, Wang, Tie, Tian, Lining, Bai, Shuping, Chen, Li, Zuo, Yanjiao, Xue, Yingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775704/
https://www.ncbi.nlm.nih.gov/pubmed/31632482
http://dx.doi.org/10.7150/jca.31787
_version_ 1783456305921392640
author Song, Hongjiang
Wang, Tie
Tian, Lining
Bai, Shuping
Chen, Li
Zuo, Yanjiao
Xue, Yingwei
author_facet Song, Hongjiang
Wang, Tie
Tian, Lining
Bai, Shuping
Chen, Li
Zuo, Yanjiao
Xue, Yingwei
author_sort Song, Hongjiang
collection PubMed
description Tumor-associated macrophages (TAM) have been shown to support tumor growth and progression by various mechanisms. However, the roles of TAM in gastric cancer (GC) peritoneal metastasis remain elusive. To explore the roles of macrophages in the process of GC peritoneal metastasis, we performed the present study. Samples from the primary GC tumor beds, surgical margins, peritoneal metastatic lesions and surrounding tissue, and the Pouch of Douglas, were collected, fixed by formalin, and embedded with paraffin. Immunohistochemistry staining for macrophages markers was performed. The peritoneal lavage was obtained from a fraction of patients to analyze the ratios of epidermal growth factor (EGF)- and vascular endothelial growth factor (VEGF)-secreting macrophages in the peritoneal cavity. GC patients with peritoneal metastasis had increased levels of macrophages and alternatively activated macrophages in the peritoneum compared to those without dissemination. Patients bearing more macrophages in the peritoneum had a poorer prognosis. GC patients bearing peritoneal metastasis harbored an increased level of angiogenesis. Macrophages in the peritoneal cavity were a source of EGF and VEGF. Macrophages in the peritoneum of GC patients play a supportive role for peritoneal metastasis by producing EGF and VEGF. Macrophages in the peritoneum might be a therapeutic target in the future.
format Online
Article
Text
id pubmed-6775704
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-67757042019-10-18 Macrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis Song, Hongjiang Wang, Tie Tian, Lining Bai, Shuping Chen, Li Zuo, Yanjiao Xue, Yingwei J Cancer Research Paper Tumor-associated macrophages (TAM) have been shown to support tumor growth and progression by various mechanisms. However, the roles of TAM in gastric cancer (GC) peritoneal metastasis remain elusive. To explore the roles of macrophages in the process of GC peritoneal metastasis, we performed the present study. Samples from the primary GC tumor beds, surgical margins, peritoneal metastatic lesions and surrounding tissue, and the Pouch of Douglas, were collected, fixed by formalin, and embedded with paraffin. Immunohistochemistry staining for macrophages markers was performed. The peritoneal lavage was obtained from a fraction of patients to analyze the ratios of epidermal growth factor (EGF)- and vascular endothelial growth factor (VEGF)-secreting macrophages in the peritoneal cavity. GC patients with peritoneal metastasis had increased levels of macrophages and alternatively activated macrophages in the peritoneum compared to those without dissemination. Patients bearing more macrophages in the peritoneum had a poorer prognosis. GC patients bearing peritoneal metastasis harbored an increased level of angiogenesis. Macrophages in the peritoneal cavity were a source of EGF and VEGF. Macrophages in the peritoneum of GC patients play a supportive role for peritoneal metastasis by producing EGF and VEGF. Macrophages in the peritoneum might be a therapeutic target in the future. Ivyspring International Publisher 2019-08-29 /pmc/articles/PMC6775704/ /pubmed/31632482 http://dx.doi.org/10.7150/jca.31787 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Song, Hongjiang
Wang, Tie
Tian, Lining
Bai, Shuping
Chen, Li
Zuo, Yanjiao
Xue, Yingwei
Macrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis
title Macrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis
title_full Macrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis
title_fullStr Macrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis
title_full_unstemmed Macrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis
title_short Macrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis
title_sort macrophages on the peritoneum are involved in gastric cancer peritoneal metastasis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775704/
https://www.ncbi.nlm.nih.gov/pubmed/31632482
http://dx.doi.org/10.7150/jca.31787
work_keys_str_mv AT songhongjiang macrophagesontheperitoneumareinvolvedingastriccancerperitonealmetastasis
AT wangtie macrophagesontheperitoneumareinvolvedingastriccancerperitonealmetastasis
AT tianlining macrophagesontheperitoneumareinvolvedingastriccancerperitonealmetastasis
AT baishuping macrophagesontheperitoneumareinvolvedingastriccancerperitonealmetastasis
AT chenli macrophagesontheperitoneumareinvolvedingastriccancerperitonealmetastasis
AT zuoyanjiao macrophagesontheperitoneumareinvolvedingastriccancerperitonealmetastasis
AT xueyingwei macrophagesontheperitoneumareinvolvedingastriccancerperitonealmetastasis