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Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway
Ras-associated protein 1A (Rap1A) is a member of the Ras subfamily of small GTP-binding proteins and is found to promote metastasis in several types of cancer. However, the functional role and molecular mechanism of action in Rap1A in esophageal squamous cell carcinoma (ESCC) is not fully understood...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775818/ https://www.ncbi.nlm.nih.gov/pubmed/31545475 http://dx.doi.org/10.3892/or.2019.7309 |
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author | Li, Qinfang Xu, Aiping Chu, Yuan Chen, Tao Li, Hongqi Yao, Liqing Zhou, Pinghong Xu, Meidong |
author_facet | Li, Qinfang Xu, Aiping Chu, Yuan Chen, Tao Li, Hongqi Yao, Liqing Zhou, Pinghong Xu, Meidong |
author_sort | Li, Qinfang |
collection | PubMed |
description | Ras-associated protein 1A (Rap1A) is a member of the Ras subfamily of small GTP-binding proteins and is found to promote metastasis in several types of cancer. However, the functional role and molecular mechanism of action in Rap1A in esophageal squamous cell carcinoma (ESCC) is not fully understood. In the present study, Rap1A was found to be upregulated in ESCC tissues and its expression was correlated with cancer stage. Functional studies revealed that Rap1A could promote ESCC metastasis by stimulating cell migration and invasion in vivo and in vitro. Further study indicated that the transcriptional factor SP1 increased Rap1A expression via promoter binding and transcription activation. Furthermore, Rap1A promoted epithelial-to-mesenchymal transition, possibly through the AKT signaling pathway. Hence, the findings of the present study indicated that Rap1A may be a potential prognostic marker or therapeutic target for ESCC. |
format | Online Article Text |
id | pubmed-6775818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-67758182019-10-10 Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway Li, Qinfang Xu, Aiping Chu, Yuan Chen, Tao Li, Hongqi Yao, Liqing Zhou, Pinghong Xu, Meidong Oncol Rep Articles Ras-associated protein 1A (Rap1A) is a member of the Ras subfamily of small GTP-binding proteins and is found to promote metastasis in several types of cancer. However, the functional role and molecular mechanism of action in Rap1A in esophageal squamous cell carcinoma (ESCC) is not fully understood. In the present study, Rap1A was found to be upregulated in ESCC tissues and its expression was correlated with cancer stage. Functional studies revealed that Rap1A could promote ESCC metastasis by stimulating cell migration and invasion in vivo and in vitro. Further study indicated that the transcriptional factor SP1 increased Rap1A expression via promoter binding and transcription activation. Furthermore, Rap1A promoted epithelial-to-mesenchymal transition, possibly through the AKT signaling pathway. Hence, the findings of the present study indicated that Rap1A may be a potential prognostic marker or therapeutic target for ESCC. D.A. Spandidos 2019-11 2019-09-12 /pmc/articles/PMC6775818/ /pubmed/31545475 http://dx.doi.org/10.3892/or.2019.7309 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Li, Qinfang Xu, Aiping Chu, Yuan Chen, Tao Li, Hongqi Yao, Liqing Zhou, Pinghong Xu, Meidong Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway |
title | Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway |
title_full | Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway |
title_fullStr | Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway |
title_full_unstemmed | Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway |
title_short | Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway |
title_sort | rap1a promotes esophageal squamous cell carcinoma metastasis through the akt signaling pathway |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775818/ https://www.ncbi.nlm.nih.gov/pubmed/31545475 http://dx.doi.org/10.3892/or.2019.7309 |
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