The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison

2,6-Diaminopyridine-3,5-bis(thiocyanate) (PR-619) is a broad-spectrum deubiquitinating enzyme (DUB) inhibitor that has been employed in cell-based studies as a tool to investigate the role of ubiquitination in various cellular processes. Here, we demonstrate that in addition to its action as a DUB i...

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Detalles Bibliográficos
Autores principales: Cowell, Ian G., Ling, Elise M., Swan, Rebecca L., Brooks, Matilda L.W., Austin, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776009/
https://www.ncbi.nlm.nih.gov/pubmed/31515282
http://dx.doi.org/10.1124/mol.119.117390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776009/
https://www.ncbi.nlm.nih.gov/pubmed/31515282
http://dx.doi.org/10.1124/mol.119.117390

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